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Acetaminophen - References
Acetaminophen is used to reduce pain and fever. Unlike NSAIDs (nonsteroidal anti-inflammatory drugs), it lacks anti-inflammatory activity. Acetaminophen is available by itself or in nonprescription and prescription-only combination products used to relieve pain and the symptoms associated with colds and flu.
Do…
- Help protect your liver with milk thistle, when using long-term Some doctors recommend 200 mg of milk thistle (Silybum marianum) extract containing 70 to 80% of the flavonoid silymarin, three times per day, for people taking acetaminophen in large amounts for more than one year and/or with other risk factors for liver problems.
- Support this medicine's effectiveness with vitamin C 3 grams of vitamin C daily with acetaminophen has been shown to prolong the amount of time it stays in the body, which might allow people to use less, thereby reducing the risk of side effects.
- Get medical help, in the case of overdose Acetaminophen toxicity is a potential medical emergency, and should only be managed by qualified healthcare professionals.
Don't…
- Drink alcohol To prevent damage to the liver, people taking acetaminophen should avoid alcohol.
- Eat foods that interfere with absorption Foods high in pectin (such as jellies), carbohydrates, and large amounts of cruciferous vegetables, such as broccoli, Brussels sprouts, and cabbage, can make it difficult for the body to absorb acetaminophen.
About this treatment
1. Vale JA, Proudfoot AT. Paracetamol (acetaminophen) poisoning. Lancet 1995;346:547–52.
2. Perry HE, Shannon MW. J Pediatr 1998;132:149–52.
3. Houston JB, Levy G. Drug biotransformation interactions in man. VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218–21.
4. Kolawole JA, Maduenyi A. Effect of zobo drink (Hibiscus sabdariffa water extract) on the pharmacokinetics of acetaminophen in human volunteers. Eur J Drug Metab Pharmacokinet 2004;29:25–9.
5. Valenzuela A, Aspillaga M, Vial S, Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med 1989;55:420–2.
6. Threlkeld DS, ed. Central Nervous System Drugs, Acetaminophen. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 247–f.
7. Campos R, Garrido A, Guerra R, Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med 1989;55:417–9.
8. Yamada S, Murawaki Y, Kawasaki H. Preventive effect of gomisin A, a lignan component of schizandra fruits, on acetaminophen-induced hepatotoxicity in rats. Biochem Pharmacol 1993;46:1081–5.
9. Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 2.
10. Threlkeld DS, ed. Central Nervous System Drugs, Acetaminophen. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1997, 247–f.
Last Review: 05-11-2011
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.
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