Alpha Lipoic Acid

 
Alpha Lipoic Acid

Alpha lipoic acid (ALA) is a vitamin-like antioxidant, sometimes referred to as the “universal antioxidant” because it is soluble in both fat and water. ALA is manufactured in the body and is found in some foods, particularly liver and yeast.

What Are "Star" Ratings?

a7_3star Reliable and relatively consistent scientific data showing a substantial health benefit.

a7_2star Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

a7_1star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:


Used for AmountWhy
Type 1 Diabetes
600 to 1,200 mg a day 3 stars Supplementing with alpha lipoic acid may protect against diabetic complications, such as nerve and kidney damage.

3 stars Type 1 Diabetes

600 to 1,200 mg a day

Alpha lipoic acid is a powerful natural antioxidant. Preliminary and double-blind trials have found that supplementing with 600 to 1,200 mg of lipoic acid per day improves the symptoms of diabetic nerve damage (neuropathy).2 , 3 , 4 , 5 In a preliminary study, supplementing with 600 mg of alpha-lipoic acid per day for 18 months slowed the progression of kidney damage in people with type 1 diabetes.6

Used for AmountWhy
Type 2 Diabetes
600 to 1,200 mg a day 3 stars Taking alpha lipoic acid may improve insulin sensitivity and help protect against diabetic complications such as nerve damage.

3 stars Type 2 Diabetes

600 to 1,200 mg a day

Alpha lipoic acid is a powerful natural antioxidant. Preliminary and double-blind trials have found that supplementing 600 to 1,200 mg of lipoic acid per day improves insulin sensitivity and the symptoms of diabetic neuropathy.7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 In a preliminary study, supplementing with 600 mg of alpha lipoic acid per day for 18 months slowed the progression of kidney damage in patients with type 2 diabetes.15

Used for AmountWhy
Migraine Headache
600 mg per day 2 stars In a small double-blind trial, supplementing with alpha-lipoic acid significantly reduced the frequency of migraine attacks.

2 stars Migraine Headache

600 mg per day

In a small double-blind trial, supplementation with 600 mg of alpha-lipoic acid once a day for three months significantly reduced the frequency of migraine attacks. However, this improvement was not statistically significant when compared with the change in the placebo group.16 Additional research is needed to determine whether alpha-lipoic acid is effective for preventing migraines.


Used for AmountWhy
Vitiligo
Refer to label instructions 2 stars In one study, supplementing with a combination of antioxidants including alpha-lipoic acid increased the effectiveness of ultraviolet light therapy.

2 stars Vitiligo

In a double-blind trial, supplementation with antioxidants for two months before and for six months during treatment with narrowband ultraviolet B light increased the effectiveness of the ultraviolet light therapy. The antioxidant supplement contained daily 100 mg of alpha-lipoic acid, 100 mg of vitamin C, 40 IU of vitamin E, and 100 mg of cysteine.17

Used for AmountWhy
Glaucoma
Refer to label instructions 1 star Alpha lipoic acid may improve visual function in people with some types of glaucoma.

1 star Glaucoma

Alpha lipoic acid (150 mg per day for one month) improves visual function in people with some types of glaucoma.18


Used for AmountWhy
Hepatitis
Refer to label instructions 1 star In one trial, a combination of alpha lipoic acid, silymarin, and selenium led to significant improvements in liver function and overall health in people with hepatitis C.

1 star Hepatitis

A potent antioxidant combination may protect the liver from damage in people with hepatitis C, possibly decreasing the necessity for a liver transplant. In a preliminary trial,19 three people with liver cirrhosis and esophageal varices (dilated veins in the esophagus that can rupture and cause fatal bleeding) caused by hepatitis C received a combination of Alpha lipoic acid (300 mg twice daily), silymarin (from milk thistle; 300 mg three times daily), and selenium (selenomethionine; 200 mcg twice daily). After five to eight months of therapy that included other “supportive supplements,” such as vitamin C and B vitamins, all three people had significant improvements in their liver function and overall health. Larger clinical trials are needed to confirm these promising preliminary results.

Also indexed as:
  • ALA (alpha-lipoic acid),
  • alpha lipoic acid,
  • antioxidant,
  • lipoic acid,
  • thioctic acid

About this treatment

How to Use It

The amount of alpha lipoic acid used in research to improve diabetic neuropathies is 800 mg per day and 150 mg per day for glaucoma. However, much lower amounts, such as 20–50 mg per day, are recommended by some doctors for general antioxidant protection, although there is no clear evidence that such general use has any benefit.

Where to Find It

The body makes small amounts of alpha lipoic acid. There is only limited knowledge about the food sources of this nutrient. However, foods that contain mitochondria (a specialized component of cells), such as red meats, are believed to provide the most alpha lipoic acid. Supplements are also available.

Possible Deficiencies

Although alpha lipoic acid was thought to be a vitamin when it was first discovered, subsequent research determined that it is created in the human body—and thus is not an essential nutrient. For this reason, deficiencies of alpha lipoic acid are not known to occur in humans.


Last Review: 05-11-2011

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Copyright © 2011 Aisle7. All rights reserved. www.Aisle7.net

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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