Are Izzie and George Leaving Grey's Anatomy?

Looks like The Chief made a no-no. Grey's Anatomy star James Pickens Jr. told Us Weekly that both Katherine Heigl and T.R. Knight will soon say sayonara to the hit medical drama.

When asked if Katherine was leaving the show, James said, "Yes, she is. Wherever Katherine goes, I wish her nothing but the best."

Then, of T.R., he added, "He's going too. He just wanted to pursue other career paths."

Here's the deal: ABC has yet to officially let Katherine and T.R. out of their contracts, so technically nothing is finalized. That said, there's still a really good chance that you won't see Izzie and George as series regulars next season.

Of course, none of this news comes as a big surprise.

Remember when Katherine Heigl withdrew her name from the 2008 Emmy race and said it was because the Grey's Anatomy writers didn't provide her with award-worthy material?

That, of course, ignited the rumors that Katherine would soon be leaving Grey's.

When that story started to die down, another Grey's conflict took center stage: sources confirmed that T.R. Knight wanted out of his contract. Apparently his unhappiness dated back to the days when Isaiah Washington used the F-word on set. His dismal mood only continued when his storyline barely existed, save for George acting supportive to Izzie's sickness.

So, how do you think they'll bow out?

My guess: Remember last week when Izzie had blood taken at the same time as a patient, and when Sadie (Melissa George) came back with the results, she said Izzie's blood was fine but the patient had cancer? Well, since we know that Melissa is leaving the show as well, I'm thinking Sadie accidently switched those viles of blood, which will lead to her losing her place as an intern at Seattle Grace. Then, Izzie will kick the bucket and George will be too emotional to continue to work there, so he'll leave as well.

What are your theories?

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