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This large thistle-like plant is native to the regions of southern Europe, North Africa, and the Canary Islands. The leaves of the plant are used medicinally. However, the roots and the immature flower heads may also contain beneficial compounds.
Reliable and relatively consistent scientific data showing a substantial health benefit.
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
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| Used for | Amount | Why |
|---|---|---|
Indigestion, Heartburn, and Low Stomach Acidity | 500 to 1,000 mg cynarin in a standardized herbal extract three times per day | Extracts of artichoke have been repeatedly shown in research to be beneficial for people with indigestion. |
| ||
| Used for | Amount | Why |
|---|---|---|
High Cholesterol | Read details for more information | Artichoke has moderately lowered cholesterol and triglycerides in some trials. |
| ||
| Used for | Amount | Why |
|---|---|---|
Irritable Bowel Syndrome | Refer to label instructions | In a preliminary study of people with irritable bowel syndrome who took an artichoke leaf extract daily for two months, 26% reported an improvement in symptoms. |
| ||
The artichoke is one of the world’s oldest medicinal plants. The ancient Egyptians placed great value on the plant—it is clearly seen in drawings involving fertility and sacrifice. Moreover, this plant was used by the ancient Greeks and Romans as a digestive aid. In 16th century Europe, the artichoke was favored as a food by royalty.
Artichoke leaves contain a wide number of active constituents, including cynarin, 1,3 dicaffeoylquinic acid, 3-caffeoylquinic acid, and scolymoside. The choleretic (bile stimulating) action of the plant has been well documented in a controlled trial involving a small sample of healthy volunteers. After the administration of 1.92 grams of standardized artichoke extract directly into the duodenum, liver bile flow increased significantly. This choleretic effect has led to the popular use of artichoke extract in Europe for the treatment of mild indigestion—particularly following a meal high in fat. In an uncontrolled clinical trial with 553 people suffering from non-specific digestive disorders (including indigestion), 320–640 mg of a standardized artichoke extract taken three times per day was found to reduce nausea, abdominal pain, constipation, and flatulence in over 70% of the study participants.
The standardized extract has also been used to treat high cholesterol and triglycerides. In one preliminary trial and one controlled trial, use of a standardized artichoke extract was found to lower cholesterol and triglycerides significantly when taken in amounts ranging from 900 to 1,920 mg per day. One preliminary trial failed to find any effect.
While scientists are not certain how artichoke leaves lower cholesterol, test tube studies have suggested that the action may be due to an inhibition of cholesterol synthesis and/or the increased elimination of cholesterol because of the plant’s choleretic action. In test tube studies, the flavonoids from the artichoke (e.g., luteolin) have been shown to prevent LDL-cholesterol oxidation—an effect that may reduce risk of atherosclerosis.
The suggested adult amount of the standardized leaf extract is 300–640 mg three times daily for a minimum of six weeks. Alternatively, if a standardized extract is not available, the amount of the crude, dried leaves is 1–4 grams, three times a day.
Last Review: 05-11-2011
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.
© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
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