OTIS: Greek for "acute" and Old German for "wealthy." Relatives: Otto, Odo, Otho, Othello, Otello, Otilio. Namesakes: Otis Redding, Otis Pike, Otto von Bismarck, Otto Rank, Otto Preminger.
OWEN: Old Welsh for "warrior" and Greek for "well born." This handsome name should be used more often. Reltives: Owyn, Evan, Ewen, Owens. Namesakes: Owen Wister, Owen Davis, Jesse Owens, "Owen Meaney."
OXFORD: Old English for "from where the oxen ford." You can't get much more academic than this. Relatives: Oxton, Oxon. Namesake: Oxford University.
OZ: Hebrew for "strength." This child will certainly be a wiz at whatever he does. Namesakes: Amos Oz, Frank Oz.