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Beta2-Agonists for Chronic Obstructive Pulmonary Disease (COPD)
Studies indicate that inhaled beta2-agonists are effective in treating symptoms of COPD and improving lung function as measured by tests (spirometry).1 They also reduce the number of COPD exacerbations. There is no evidence of their effect on the progression of the disease.2
Compared to placebo:
- Inhaled short-acting beta2-agonists are effective in treating a person whose symptoms are rapidly getting worse (COPD exacerbation) and improving lung function and shortness of breath in stable COPD.3, 2
- Inhaled long-acting beta2-agonists improve lung function and improve symptoms such as shortness of breath.2
Results vary from one person to the next. For some people with COPD, beta2-agonist medicines make breathing much easier. For others, they do not help.
Combining medicines may help your lung function. Using a beta2-agonist:
- With an anticholinergic may help your lung function more than using either medicine alone.2
- With an inhaled corticosteroid may result in improved shortness of breath and less use of relief medicine compared to placebo or compared to either medicine used alone.4, 5 The combination also resulted in fewer COPD exacerbations compared with placebo, but it increased the risk of pneumonia.4
Combining medicines also may reduce the risk of side effects compared to increasing the dose of one medicine.6
| By: | Healthwise Staff | Last Revised: May 4, 2010 |
| Medical Review: | Caroline S. Rhoads, MD - Internal Medicine Ken Y. Yoneda, MD - Pulmonology | |
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