Cluster Headache - References

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Cluster Headache
A sharp, recurring pain around the eye or upper face may mean more than your average headache. According to research or other evidence, the following self-care steps may be helpful.
  • Manage pain with melatonin

    Take 10 mg of this natural hormone before bedtime to decrease the frequency of cluster headaches

  • Consider capsaicin Consult a healthcare provider experienced with intranasal capsaicin treatment, which may ease the pain and reduce recurrences
  • Experiment with oxygen therapy See a healthcare provider experienced with oxygen therapy to find out if it reduces the pain of cluster headache attacks
Also indexed as:
  • ciliary neuralgia,
  • cluster headache,
  • cluster headaches,
  • histamine cephalgia,
  • Horton's headache,
  • migrainous neuralgia,
  • red migraine
Alternative Treatments

About this treatment

1. Mendizabal JE, Umana E, Zweifler R. Cluster Headache: Horton’s Cephalalgia Revisited. South Med J 1998;91:606–17 [review].

2. Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol 1985;43:362–3.

3. Kudrow L. Response of cluster headache attacks to oxygen inhalation. Headache 1981;21:1–4.

4. Mendizabal JE, Umana E, Zweifler RM. Cluster Headache: Horton’s Cephalalgia Revisited. South Med J 1998;91:606–17 [review].

5. DiSabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993;52:243–5.

6. DiSabato F, Giacovazzo M, Cristalli G, et al. Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients. Headache 1996;36:221–3.

7. Pascual J, Peralta G, Sanchez U. Preventive effects of hyperbaric oxygen in cluster headache. Headache 1995;35:260–1.

8. DiSabato F, Rocco M, Martelletti P, Giacovazzo M. Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways. Undersea Hyperb Med 1997;24:117–22.

9. Mendizabal JE, Umana E, Zweifler R. Cluster Headache: Horton’s Cephalalgia Revisited. South Med J 1998;91:606–17 [review].

10. Trotsky MB. Neurogenic vascular headaches, food and chemical triggers. Ear Nose Throat J 1994;73:228–30.

11. Levi R, Edman GV, Ekbom K, Waldenlind E. Episodic cluster headache. II: High tobacco and alcohol consumption in males. Headache 1992;32:184–7.

12. Manzoni GC. Cluster headache and lifestyle: remarks on a population of 374 male patients. Cephalalgia 1999;19:88–94.

13. Sicuteri F, Renzi D, Geppetti P. Substance P and enkephalins: a creditable tandem in the pathophysiology of cluster headache and migraine. Adv Exp Med Biol 1986;198B:145–52.

14. Sicuteri F, Fanciullacci M, Nicolodi M, et al. Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 1990;30:69–79 [review].

15. Lynn B. Capsaicin. Actions on nociceptive C-fibers and therapeutic potential. Pain 1990;41:61–9.

16. Sicuteri F, Fusco BM, Marabini S, et al. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989;5:49–53.

17. Fusco BM, Marabini S, Maggi C, et al. Preventative effect of repeated nasal applications of capsaicin in cluster headache. Pain 1994;59:321–5.

18. Fusco BM, Fiore G, Gallo F, et al. “Capsaicin-sensitive” sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. Headache 1994;34:132–7.

19. Marks DR, Papoport A, Padla D, et al. A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 1993;13:114–6.

20. Chazot G, Claustrat B, Brun J, et al. A chronobiological study of melatonin, cortisol, growth hormone, and prolactin secretion in cluster headache. Cephalalgia 1984;4:213–20.

21. Waldenlind E, Gustafsson SA, Ekbom KA, Wetterberg L. Circadian secretion of cortisol and melatonin during active cluster periods and remission. J Neurol Neurosurg Psychiatry 1987;50:207–13.

22. Leone M, Lucini V, D’Amico D, et al. Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. Cephalalgia 1995;15:224–9.

23. Leone M, Lucini V, D’Amico D, et al. Abnormal 24-hour urinary excretory pattern of 6-sulphatoxymelatonin in both phases of cluster headache. Cephalalgia 1998;18:664–7.

24. Leone M, D’Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16:494–6.

25. Peres MFP, Rozen TD. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia 2001;21:993–5.

26. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulfate relieves cluster headaches in patients with low serum ionized magnesium levels. Headache 1995;35:597–600.

27. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulfate rapidly alleviates headaches of various types. Headache 1996;36:154–60.

Last Review: 05-11-2011

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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