Who He Is: James Franco's little brother, of course! Like his big bro, Dave, 25, dropped out of college to pursue acting. (Though if he's following in his brother's footsteps, he'll one day return with a vengeance!) Franco got his big break as spoiled-brat med student Cole Aaronson in the final season of Scrubs. Also: he may or may not be dating Emma Roberts.
Where to See Him: Franco is already gaining a cult following of his own, thanks to some daring and hilarious videos on comedy Web site FunnyorDie.com -- several which costar his Oscar-nominated big bro. He'll soon be appearing in the vampire flick Fright Night and will play the villain in the big-screen remake of 21 Jump Street.