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DHEA for Sports & Fitness
DHEA
Why Do Athletes Use It?*
Some athletes say that DHEA promotes the loss of body fat.
What Do the Advocates Say?*
Since it is a precursor to testosterone, dehydroepiandrosterone (DHEA) may help build muscle mass. However, it is unusual for anyone under the age of 35 or 40 to have low DHEA levels. As we age, the body’s production of DHEA declines, so people over 40 should ask their doctors to check their DHEA levels. Although it is sold over the counter, it’s best to take DHEA only with a doctor’s supervision.
*Athletes and fitness advocates may claim benefits for this supplement based on their personal or professional experience. These are individual opinions and testimonials that may or may not be supported by controlled clinical studies or published scientific articles.
Also indexed as:
- dehydroepiandrosterone,
- DHEA,
- fitness,
- physical fitness,
- Prasterone
About this treatment
DHEA
How Much Is Usually Taken by Athletes?
One hundred mg per day of DHEA was effective in one double-blind trial for improving strength in older men, but 50 mg per day was ineffective in a similar study of men and women. DHEA has not been effective for women or younger men in other studies.
Side Effects
Experts have concerns about the use of DHEA, particularly because long-term safety data do not exist.
Side effects at high intakes (50–200 mg per day) appear to be acne (in over 50% of people), increased facial hair (18%), and increased perspiration (8%). In a preliminary trial, DHEA was also reported to induce less common side effects, including breast tenderness, weight gain, mood alteration, headache, oily skin, and menstrual irregularity in some people. Since this trial was not controlled, some of these less common “side effects” might have occurred even with a placebo. A case of mania has been reported in an older man who took 200–300 mg of DHEA per day for six months. However, in that case report, other causes of mania could not be ruled out.
Significant increases in testosterone levels in both men and women have been reported in some trials. Other reports have found this change in women but not in men. An increase in testosterone might increase the risk of several cancers, and high amounts of DHEA have caused cancer in animals. Moreover, a possible link between higher DHEA levels and risks of prostate cancer in humans has been reported. At least one person with prostate cancer has been reported to have had a worsening of his cancer, despite feeling better, while taking very high amounts (up to 700 mg per day) of DHEA.
While younger women with breast cancer may have low levels of DHEA, postmenopausal women with breast cancer appear to have high levels of DHEA, which has researchers concerned. Most, but not all, studies have found that as DHEA blood levels increase, so does the risk of breast cancer.
Supplementation with high levels of DHEA (100 mg per day) has adversely affected other indicators of cancer risk in both women and men. Elevated DHEA levels have been reported to be associated with both higher, and lower risk for ovarian cancer. The reason for this discrepancy is unknown.
The lack of knowledge about how DHEA supplementation might affect cancer risks provides a reason for caution. Until more is known, people with breast or prostate cancer or a family history of these conditions should avoid supplementing with DHEA.
Although anticancer effects of DHEA have also been reported, they involve trials using animals that do not process DHEA the way humans do. Therefore, these positive effects may have no relevance for people.
Some doctors recommend that people taking DHEA have liver enzymes measured routinely. Anecdotes of DHEA supplementation (of at least 25 mg per day) leading to heart arrhythmias have appeared.
The relationship between DHEA, blood pressure, and heart disease is poorly understood. Increased blood levels of DHEAS have been associated with increased blood pressure and other cardiovascular risk factors in some, but not all, studies. One study found that people with hypertension had significantly decreased blood levels of DHEA. Until clinical trials clear up these inconsistencies and confirm its safety, people with hypertension should avoid using DHEA, except under the close supervision of a doctor.
At only 25 mg per day, DHEA has lowered HDL cholesterol while increasing insulin-like growth factor (IGF). Decreasing HDL could increase the risk of heart disease. Increasing IGF might increase the risk of breast cancer.
Interactions with Supplements, Foods, & Other Compounds
At the time of writing, there were no well-known interactions with this supplement.
Interactions with Medicines
Certain medicines interact with this supplement.
 | Some medicines may increase the need for this supplement. |
|---|---|
 | Some medicines interact with this supplement, so they should not be taken together. |
 | Some interactions between this supplement and certain medicines require more explanation. Click the link to see details. |
Note: The following list only includes the generic or class name of a medicine. To find a specific brand name, use the Medicines Index.
| Beclomethasone |
|---|---|
| Budesonide |
| Clonidine |
| Flunisolide |
| Fluoxetine |
| Fluticasone |
| Insulin |
| Levalbuterol |
| Diltiazem |
| Amlodipine |
| Amlodipine-Benazepril |
| Metformin |
| Methyltestosterone |
Last Review: 05-11-2011
Copyright © 2011 Aisle7. All rights reserved. www.Aisle7.net
Learn more about Aisle7, the company.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.
© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
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