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23 Fall Movies We Can't Wait to See!

From Brad Pitt's Moneyball to The Twilight Saga: Breaking Dawn, check out our picks for the season's coolest films (25 Photos)

Tom DiChiara on Aug 17, 2011 at 3:35AM

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Summit Entertainment

50/50 (Sept. 30)

The Plot: The film follows the friendship of 25-year-old Will Reiser (Joseph Gordon- Levitt), who is diagnosed with spinal cancer, and the best bud (Seth Rogen) who helps him cope with it. But here's the twist: It's a comedy!

The Buzz: Mining cancer for laughs sounds like a tough proposition, but the film is based on the real-life story of Rogen's pal Reiser (now in remission), who wrote the screenplay, and features Rogen playing a version of himself. So don't be surprised when you see Gordon-Levitt's character dealing with the side effects of chemo one moment and using his cancer to score women the next.

Good for Kids? Only if they're mature way beyond their years: This one's rated R and deals with some weighty -- and raunchy -- stuff.