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Fibromyalgia - Medications
Medicines do not cure fibromyalgia. But some medicines may help improve fibromyalgia symptoms, especially muscle pain and frequent waking during the night. Not all people with fibromyalgia will need, want, or benefit from medicines. But people with more severe pain, sleep problems, or depression that disturbs their daily life may find medicines helpful.
Antidepressants are often used to treat symptoms of fibromyalgia. This does not mean that the condition is "all in your head." Antidepressants may help by improving sleep and mood or by blocking pain signals. Many people with fibromyalgia seem to benefit from the use of these medicines.
Fibromyalgia symptoms in different people respond to different medicines. Your doctor may try more than one medicine before finding one that works best for you. You may also find that a medicine that has been helping your symptoms seems to become less effective over time. Talk with your doctor if you are not getting relief. He or she may try a different medicine or make suggestions for helping find new ways to modify your activity, sleep, and stress.
Medication Choices
Often medicines may be combined (such as fluoxetine and amitriptyline) for the most effective treatment of symptoms of pain and sleep disruptions.
Certain types of antidepressants may be used to improve sleep, relieve pain and fatigue, and, in some cases, treat depression. These improvements in symptoms may allow you to feel better and to be more active. Antidepressants used for fibromyalgia include:6
- Tricyclic antidepressants, such as amitriptyline or cyclobenzaprine (Flexeril). Cyclobenzaprine is usually thought of as a muscle relaxant, rather than an antidepressant, but it is the same type of drug as a tricyclic antidepressant.
- Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac) or paroxetine (Paxil).
- Serotonin and norepinephrine reuptake inhibitors (SNRIs)—also called mixed (or dual) reuptake inhibitors—such as duloxetine (Cymbalta), milnacipran (Savella), or venlafaxine (Effexor).
- Atypical antidepressants, meaning drugs that don't fit well into the general categories of antidepressant medicines. Bupropion (Wellbutrin) is an example of an atypical antidepressant that is used for fibromyalgia.
A seizure medicine (anticonvulsant) called pregabalin (Lyrica) is used to treat fibromyalgia. Pregabalin may help reduce pain, sleep problems, and fatigue.7
Other medicines are being studied and used for treating fibromyalgia, including:
- Another seizure medicine (anticonvulsant) called gabapentin (Neurontin).8
- Pain medicines such as tramadol (Ultram), sometimes combined with acetaminophen.3, 9
- A medicine called sodium oxylate (Xyrem) that is used for sleep disorders such as narcolepsy.10
Nonprescription pain relievers, such as acetaminophen (for example, Tylenol) or nonsteroidal anti-inflammatory drugs (NSAIDS, such as ibuprofen or aspirin) usually are not very helpful in treating day-to-day symptoms of fibromyalgia. But they may be useful in reducing severe pain caused by a flare-up of symptoms. You should check with your doctor if you need to keep taking these medicines, because they may harm your stomach, kidneys, or in rare cases, your liver. Your doctor may want to monitor you if you take acetaminophen or NSAIDs daily.
What To Think About
In general, medicines are only a part of the long-term treatment of fibromyalgia. They may help break the cycle of pain and sleep problems when symptoms flare up. But medicines usually are part of a larger treatment plan that focuses on exercise and other types of treatment.
Narcotic pain relievers and sleep aids that can lead to addiction are rarely used to treat fibromyalgia. They can be helpful to some people who have severe symptoms. But you can become dependent on them over time, and the treatment can become worse than the fibromyalgia symptoms.
| By: | Healthwise Staff | Last Revised: November 12, 2010 |
| Medical Review: | Kathleen Romito, MD - Family Medicine Richa Dhawan, MD - Rheumatology | |
© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
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