Vioxx Pulled from Market

iVillage Member
Registered: 11-17-2003
Vioxx Pulled from Market
1
Thu, 09-30-2004 - 9:07pm
Arthritis Drug Vioxx Pulled From Market
New study shows long-term use raises heart attack, stroke risk

By E.J. Mundell
HealthDay Reporter



THURSDAY, Sept. 30 (HealthDayNews) -- The maker of the popular arthritis drug Vioxx is removing it from markets worldwide after a new study found that long-term users face increased risks for heart attack and stroke.


The three-year study, designed to see if daily 25-milligram doses of Vioxx might inhibit recurrence of precancerous polyps in the colon and rectum, found the cardiovascular risks began to appear approximately 18 months after starting on the drug.


Read more at:


http://www.ivillagehealth.com/news/drugs/content/0,,412636_645651,00.html

IVHealth Ruth Ann
Assistant Community Moderator/Health Librarian
rjohnson@mail.ivillage.com

IVHealth Ruth Ann
Community Leader/Ask the Health Librarian

iVillage Member
Registered: 11-17-2003
Mon, 10-11-2004 - 10:06pm
Safety of All Cox-2 Drugs Questioned
Expert says they work on same heart mechanism as recalled Vioxx

By E.J. Mundell
HealthDay Reporter



FRIDAY, Oct. 8 (HealthDayNews) -- A week after drug giant Merck & Co. withdrew its arthritis drug Vioxx from the market, doubts are being raised about the safety of the two other approved medications in this class, Bextra and Celebrex.


In an article released Thursday by the New England Journal of Medicine, an expert with a long history of research in the cox-2 inhibitor class of medications said cardiovascular problems seen with Vioxx may yet surface with the other two drugs.


The problem, said Dr. Garrett A. FitzGerald, is that all cox-2 inhibitors suppress the production of a heart-protecting fat called prostaglandin I2.


"Vioxx, Celebrex and Bextra all have the same effect on this biochemical system. Therefore, until proven otherwise, evidence would suggest that this mechanism would involve all drugs in this class," explained FitzGerald, who is chairman of pharmacology at the University of Pennsylvania's Institute of Translational Medicine and Therapeutics.


Read more at:


http://www.ivillagehealth.com/news/topnews/content/0,,418445_645952,00.html

IVHealth Ruth Ann
Assistant Community Moderator/Health Librarian
rjohnson@mail.ivillage.com

IVHealth Ruth Ann
Community Leader/Ask the Health Librarian