Our kitty, Hobo, is gone....

Our sweet kitty, Hobo, who was a stray we took in, has disappeared. My SIL fed both cats Thursday morning. We didn't get home from out of town until 2 a.m. and only Milo was here. Hobo hasn't been seen since. We went around and asked all our neighbors today, and no one had seen her. One neighbor said they have lost 3 cats to coyotes since they have lived here. I am having a really hard time w/ it, she was a very sweet and loving cat.