OT-Melissa and Hubby

iVillage Member
Registered: 09-09-2007
OT-Melissa and Hubby
14
Sun, 01-11-2009 - 8:28pm

I was wondering what you both thought of this...

"The first baby in the UK tested before conception for a genetic form of breast cancer has been born."

http://news.bbc.co.uk/2/hi/health/7819651.stm

"Pre-implantation genetic diagnosis (PGD) involves taking a cell from an embryo at the eight-cell stage of development, when it is around three-days old, and testing it.

This is before conception - defined as when the embryo is implanted in the womb.

Doctors then select an embryo free from rogue genes to continue the pregnancy, and discard any whose genetic profile points to future problems. "

Photobucket Thanks to Andie for my siggy!



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iVillage Member
Registered: 06-24-2008
Sun, 01-11-2009 - 11:07pm

Well -- as much as I love science and medicine .. I also feel that just because we can do something doesn't mean we should. One the surface it seems like "Great! Now this family will never have to worry about cancer caused by that one gene!" ... buuut ... I also take issue with the idea of intentionally altering or selecting an embryo to be born based on genetic makeup or features that one assumes he/she will have (ie selecting gender, hair / eye color). Maybe that's the traditional part of me .. I like to have a little surprise and maybe that's messing around with nature a little too much.

I will also pass this along to DH to see what his thoughts are ;) ... though it's my guess that he'll be feeling about the same way about it as I do!



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Lilypie Expecting a baby Ticker


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iVillage Member
Registered: 09-09-2007
Sun, 01-11-2009 - 11:17pm
I completely agree. Ethically, I didn't think you two would say "Hey! That's fantastic!" lol
I wanted to see what you (and dh) had to say about it scientifically. Letting us all know that your dh is a scientist may not have been the best idea. Let me know if he gets sick of being bugged about stuff! ;-)
Photobucket Thanks to Andie for my siggy!



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iVillage Member
Registered: 06-24-2008
Sun, 01-11-2009 - 11:29pm

Haha ... no, he's not bugged .. it gives him something to do ;)

He's got a busy day tomorrow but I'll send him the article and if he has a free minute he can reply -- otherwise it might take him a couple days :)



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Lilypie Expecting a baby Ticker


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iVillage Member
Registered: 04-09-2008
Fri, 01-16-2009 - 12:50pm

Sorry, I realize this was for Melissa, but I read it (sorry Melissa...)


They're now doing this for "athletic ability".

Rands

iVillage Member
Registered: 09-09-2007
Fri, 01-16-2009 - 2:44pm
ITA!
It's slightly sickening that people are so picky when it comes to the child they create. I'm sure there are plenty of barren women who'd love to have a child with no jump shot!
Photobucket Thanks to Andie for my siggy!



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iVillage Member
Registered: 04-09-2008
Fri, 01-16-2009 - 3:35pm

Very true!

Rands

iVillage Member
Registered: 10-18-2007
Tue, 01-20-2009 - 8:30pm

I had a question for your hubby as it relates to HIV. I've been rather submersed in HIV/AIDS literature since Maggiore died. Is he studying any specific mechanism by which HIV destroys CD4s? There are several theories, which do you (or DH) place most of your "stock" and what are your long term thoughts on antiretroviral treatment for those diagnosed with HIV infection but are asymptomatic?

(Sincere questions)

Thanks,

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iVillage Member
Registered: 06-24-2008
Wed, 01-21-2009 - 12:22am
He's definitely the HIV expert .. not me, at all!! :) I passed the question along to him and will post the answer when he gets it typed up!


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Lilypie Expecting a baby Ticker


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iVillage Member
Registered: 06-24-2008
Wed, 01-21-2009 - 11:00am

Response to the first part: (he's working on the rest)

Hello,
Although most of my work was not on the pathogenesis side of HIV but
rather focused on viral genetics and antigenecity of the HIV gp120
envelope as it changes over time I can still answer your question as I
have had some decent exposure to this subject. Since the immune
system is pretty complex and involves multiple contributing factors in
developing disease there is actually not necessarily one set way that
the body will lose T-cells. Most immunologists, however, will agree
that there are probably three primary mechanisms by which CD4+ cells
are depleted in HIV infections. First, remember that HIV is a
retrovirus meaning that it has the ability to reverse transcribe its
RNA genome and insert it as DNA into the host cell (generally a CD4+
T-cell although other cells such as macrophages and dendritics can be
infected as well). As these cells divide they replicate the viral DNA
and then at a specific time the cell's machinery becomes hijacked and
the virus begins replicating itself faster than the cell until
continuous replication causes the cell to die via lysis (or bursting)
as its membrane becomes compromised. Secondly, the virus has 15
proteins, some of which actually serve to dysregulate T-cells and
actually send them into overdrive and cause them to commit suicide via
a process known as apoptosis. Third, viral antigens produced in the
cytosol of the host CD4+ cell will be picked up and presented by MHC1
on the surface of infected CD4+ T-cells and this in turn will cause
killing of infected cells by CD8+ T-cells. I also saw a presentation
several years ago by a postdoctoral fellow in Rafi Ahmed's lab at
Emory University who was showed that CD8+ cells also become
"exhausted" by HIV and this leads to their downregulation and allows
the virus to gain a foothold.



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Lilypie Expecting a baby Ticker


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iVillage Member
Registered: 10-18-2007
Wed, 01-21-2009 - 11:19am

Thanks Melissa, and Anthony? (I think I saw Anthony somewhere in our discussions?)

I've been a little obsessed with ADCC lately. And there are literally hundreds of papers about it... I expect I'll be reading for a while.

Thanks again,

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