Cycle 2: Antagonist Protocol? Cycle 1 Flare protocol resulted in only 1 egg.

iVillage Member
Registered: 03-13-2006
Cycle 2: Antagonist Protocol? Cycle 1 Flare protocol resulted in only 1 egg.
11
Thu, 10-20-2011 - 12:45pm

I'm curious what you guys know about antagonist protocols for poor responders?

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iVillage Member
Registered: 08-08-2011

I am NOT familiar with these specific Protocols. However, having gone through a few IUI's and on to my THIRD IVF...I have More experience than one SHOULD with infertility. Even though we had success with our IVF cycles (though lost 2 of our 3 triplets in IVF#1) (Lost Baby in IVF #2)....we DID get our Beuatiful daughter in IVF #1! Protocols Vary....and it is a "game of chance".....but our belief..even if it finacially KILLS us....is that until we have really tried EVERYTHING, we don;t know what works...and we will have a lot of regret and "what if's" if we don;t TRY.

Don;t be sad..... Remember....the potential IS there. I know that for some...IVF and treatments DON't work.... But they ONLY know that if they TRY. There is always hope....right? We have to hang onto THAT. If we don;t have that...we have NOTHING! There are MANY people who move onto adoption....or even Donor eggs (Which, due to my age...we are doing THAT this IVF cycle). For me...the biology is not nearly as crucial as GROWING OUR FAMILY). Have you discussed Donor eggs with your RE??? I mean...if you are going to spend ALL of that money....and want the very best chance...you have decide...is it JUST biology that makes afamily?? Or do you want to participate in a life growing inside of you...and then nurture it as it joins the outside world?? In our case, due to the success then failure of our last cycle....we decided my eggs are not trustworthy. And so...for the SAME cost as our other cycles...we are using Donor Eggs and hopefully...hopefully....increasing our odds.

You are NOT alone....... we are all here...and more or less in the same boat. If you need us.....here we are!

Lindz

iVillage Member
Registered: 05-09-2005

Hi there,

I read

Chris


Me, 38, dh, 35


3 IUI's - BFN


IVF #1 - Jan '08 - BFP - beautiful baby boy born 10/10/08


IVF cycle #2 - TTC

iVillage Member
Registered: 09-29-2010

Hi there! I have DOR too and had a terrible 1st cycle. The antagonist worked for me, but I also dropped the BCPs (they can suppress an already poor responder) and added in estrogen priming beforehand. I would definitely ask about that!!

Let me know if you have questions and good luck!

iVillage Member
Registered: 03-13-2006
I did drop the BCPs and we are doing the estrogen priming too! That is good news to hear... Thanks!!!!

I don't know much about the details of my cycle yet. I know I do some patch and injections early (estrogen maybe?) then after AF start Menopur and Gonal-F.
iVillage Member
Registered: 04-23-2007
I can relate! I have DOR also. I dragged my feet for many years with moving forward with IVF, thinking that it would happen on it's own. I wish I had done IVF at age 29 when it was first recommended. Now I am 37. My FSH has been normal. I did my first 2 cycles with lupron protocol and only produced 1 egg each time. I don't recall all the details of those cycles and what meds were given. I know each time I used lupron, the 2cnd was a much lower dose. Both IVF cycles were cancelled. That clinic told me that my next option was donor eggs.

I went to a different clinic. I have done a total of 4 cycles with my new RE with an estrogen priming protocol. I was so nervous that I wouldn't get any eggs, but I did get eggs and went on to ET!!! So don't give up. Trying a different protocol may work for you. I remember being on pins and needles with my 1st cycle with new RE, and couldn't believe it when I got 4 eggs. Here are the details:

1st cycle I did 3 months of estrace 1mg beforehand, and then increased the dose after ovulation, and took that until I started stims. I did menopur/follistim, ended up with 4 eggs that cycle. The unfortunate part was that I ovulated early and it was too late to retrieve the eggs by the time I made it to the ER.

2cnd cycle same meds, but added more of each dose and ganirelix (so I wouldn't ovulate too soon again), 4 eggs were retrieved, but unfortunately did not make it to transfer.

3rd cycle (May 2011) took 25mg DHEA for 6 months beforehand, estrace priming, slightly higher dose of meds (Follistim, menopur, ganirelix) , retrieved 7 eggs, 5 fertilized, 3 transferred, resulted in chemical.

4th cycle (Oct 2011)- DHEA 25mg, higher dose of estrace priming, same stims and ganirelix, 9 eggs retrieved, 5 fertilized, 3 transferred, BFN. I am now waiting to start my period. I will be following up with RE for feedback about what he thinks happened. I think now I am struggling with quality of eggs due to my age.

Don't give up! You are young and I wish I had moved forward with IVF at age 29. I think I would have a much different outcome even with DOR due to now I am 37 and have to deal with the egg quality issue. Hope this helps and good luck to you!!

Daana
iVillage Member
Registered: 03-13-2006
That helps tons. I read your message to my husband on our date night tonight! He finds other people's cycles less encouraging than I do, but he's not the one doing 5 injections a day and having someone stand watch outside his office door so he can mix meds and inject them.

My doctor also gave us DHEA. I'm taking 25mg 3x/day. No major side effects except my skin is like being 14 again and that makes me self conscious. But I'll do almost anything to get a BFP. Our RE doesn't believe in the stuff - he has only prescribed it 12 times in his practice. But we asked about it and he said it wouldn't hurt. So we are doing that for 3 months. He said if we get 4 eggs this time he will give himself credit, 5 and maybe DHEA helped, but any more than 5 and he would love to call us a positive stat on DHEA. So even if it doesn't help, if he can get 4 eggs or 5 eggs he thinks he will get good quality embryos with ICSI (DH has poor morph) because my eggs are still young. He figured one good embryo is like a 25% chance, a transfer of 2 a 40% chance. Our clinic has good stats which is part of the reason we like it so much. And they don't selectively exclude non-ideal candidates to boost stats like some clinics. We know he will cycle us once or maybe twice more after this if it doesn't work. Then we will have to move to donor eggs. We have someone very important to me lined up but hoping we don't have to go that route. Plus the cost of that (can't claim the drug money for HER cycle) would mean we'd have to wait a year, maybe 2.

We start our cycle any day now depending on when AF shows up. That puts us at transfer ~Dec8-10. Assuming we make it that far, unlike last time. A Christmas BFP would be great. A cancelled or failed cycle not so great. I'm just hoping this totally opposite protocol works for us. I think our RE believes it will work. Not that we'll get 10 or 15 eggs, but it only takes one good embryo...

Thank you for sharing, thanks a Lot. I'm sorry your cycles haven't worked out so far. Hopefully your RE can shed some light on what might be wrong. Have you considered donor eggs, or is that not the road for you? We know adoption is not for us... The pregnancy experience is important. That first ultrasound, the first heart beat... We want those things. We weren't ok with egg donor until we figured out someone who is pretty much family anyway and she jumped at the chance without us asking because she wants us to be able to have a family. She made me realize that if she was the donor I would still feel 100% like it was my child, something we don't think we'd feel otherwise.
iVillage Member
Registered: 04-23-2007
I am so happy to have been able to share my story with you and feel positive you will have a much better outcome with the different protocol. I too was desperate to hear a story like mine, to give me some hope. It only takes 1 good embryo and I feel positive for you that it will work! Are you taking estrace also? If not you may want to ask RE about it.

As for me, I'm not sure what's next. I have not felt open to adoption, occasionally feel that it might be nice to use donor eggs. My RE also does not exclude those who are not ideal candidates either, which was why I went to him. For now I will just take some time to recover. Good luck to you!!

Daana
iVillage Member
Registered: 07-17-2008

Have hope.

Bewford

36 dh 36 dx - undetermined
1st IVF May 2008 BFN

2nd IVF July 2008 BFP with twins
iVillage Member
Registered: 03-13-2006
Thank you for sharing. I'm really hoping things go better this time. After last cycle I don't feel very positive but I'm trying. I'm hoping this different protocol will work out. I'm never gonna get a bunch of eggs, but it would be nice to at least make it to retrieval this time, and get a couple embryos. Our RE is confident that the chances are very good if we can get that far.

We had our appt to pick up our drugs yesterday. Made me sad to be back at the clinic after 2 months off. The time off was nice. But now it's back to reality, estrogen patches (new), cetrotide (new), menopur (Luveris last cycle) and gonal-f (same), mood swings, injection site irritation, having someone cover my door at work for mid-day injections, sleepless nights and sore tired eyes. I would love to have an xmas day BFP (bad timing for 2ww though).
iVillage Member
Registered: 02-06-2008
I think we are pretty close in timing and almost the same protocol. I start my Estrogen patches Nov 8 if all goes well. Having some gastro issues after a bad batch of antibiotics. Not a bad batch but apparently I'm the 1% it messes with yeh. Hope I can continue to at least a retrieval.

My last cycle resulted in two transferable on day three poor quality that resulted in a chemical pregnancy.

Here's to hoping for a few but excellent quality!!!

I'll be cheering you on!
Shel
Me 34 DH 50 Sept 2007 failed VR November 2008 2nd failed VR April 2009 failed TESA 4% motility with none to use after freeze. DH massive infection post-op two rounds of antibiotics. Set for first IVF cycle with fresh TESA and Donor back-up; ER July 13

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