Cycle #4 very troubling

iVillage Member
Registered: 09-27-2003
Cycle #4 very troubling
16
Tue, 04-27-2004 - 9:44am
Hi everyone,

I just thought I would update you on my progress in Cycle #4. I am still overseas, being seen by that second "famous" RE.

Per yesterday's ultrasound, I have only one follicle that looked promising at 13 mm. I am still on Gonal-F until further notice. This is of concern since, for all three previous cycles, I had already had an IUI by now, with 7-8 follicles at 18 or 20 mm +! I called my RE in the States, and he said not to worry, every cycle is different and if I was going to be a "non-responder" it would not happen suddenly from one month to the next. I'm still pretty worried though - I feel as though something has just gone wrong this time.

I was also told it is still worth doing IUI, even if there is only one follicle. I have my strong doubts about that. We'll see.

Best wishes and baby dust to everyone,

Lisa

TTC #1 since July 2003

Injectibles cycle #3

Cycle day #14

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iVillage Member
Registered: 06-16-2003
Tue, 04-27-2004 - 1:15pm
Hi Lisa,

I just wanted to wish you good luck...I wish I could tell you something more but I am new to this and have questions myself.....as I mentioned in another post, I suppose we have to trust our doctors at some point and just go with it....

Best of luck to you!!! You will be in my thoughts..

Barb

P.S. They tell me it only "takes one"!!

iVillage Member
Registered: 02-05-2004
Tue, 04-27-2004 - 3:28pm
Hi Lisa

listen to your what your US Dr said, I've heard that every cycle is different. If you're still getting 7-8 follicles, that's great! Actually, my RE office must be conservative, they cancel IUI's if there are more than 5 follies. And perhaps this month your ovaries are just taking it a bit easy?...

And about the IUI for 1 follicle, I usually only get one really good folly and I totally feel it's worth it. We know that there are more sperm making it to where they need to be, and there only needs to be one egg. If we were doing things the 'old fashioned way', it would be just bd'ing and 1 egg so again the odds are better with IUI.

Just be positive and think good thoughts! Sometimes it's the month that seems the least likely that gets you the BFP!!

God bless! sending tons of Baby Dust "airmail"!!

keep us updated

JnAnB
iVillage Member
Registered: 12-26-2003
Tue, 04-27-2004 - 3:38pm
Hi Lisa,

Are you on the sames meds @ the same amount as your last cycle? Is there anything you can pinpoint that you are doing differently this time as far as diet etc? Since you are overseas it is possible that your body could be adjusting to different water, spices/herbs in food, altitude, things like that. Most Re's really know nothing about nutrition. I feel no matter how good they are this is a hinderence. If there is anything you notice that has changed that could be your answer.

Let us know how you do.

***********Baby Dust coming to you!!!!*********

Lisa
Lilypie Baby Days
iVillage Member
Registered: 11-30-2003
Tue, 04-27-2004 - 4:19pm
Lisa: A friend of mine was really upset because she only had one follicle with a mega dose of Clomid...she also was late in her cycle when she ovulated. We used to commiserate about our frustration with the whole ttc process. Now, she just listens to me vent...because her beautiful baby is due at the end of August!!

I'm obviously not an RE, but at least for her a slow steady growing follicle did the trick..hope that's the case for you too!! One healthy follie is all you need!!

Tons of baby dust across the miles!!

Margie

iVillage Member
Registered: 09-27-2003
Tue, 04-27-2004 - 7:32pm
Dear Barb, JnAnB, Lisa, Margie,

Thanks so much for your posts! I found them very encouraging.

The only difference between cycles #1-3 and cycle #4 is that I am on Gonal-F, not Follistim, because the pharmaceutical company changed the dosage in which Follistim is available. My REs said they are actually exactly the same thing. In fact, this cycle started with 3 vials for the first two days (75 IU each), while the previous 3 cycles used only 2 vials every day from the start.

There was, however, a controversy regarding how to inject Gonal-F. Even though the instructions say to inject it subcutaneously, my RE in NY insists on intramuscular injections as being more effective and requiring less medication (seemingly the pharmaceutical company formulated the medication to be administered subcutaneously so more women could inject themselves, but that is the only reason), whereas the European RE says to follow the instructions and inject subcutaneously. Does anyone else know about this?

Thanks again for your input and support. I will keep you posted (after my appointment tomorrow)!

All the best to you and baby dust!!

Lisa

iVillage Member
Registered: 02-05-2004
Tue, 04-27-2004 - 8:33pm
Hi Lisa,

maybe you're just responding to Gonal F differently? and that it doesn't work as well for you as the other med?

I read thru the package insert for my Gonal F. They did a study on the effectiveness of Gonal F when injected intramuscularly and subcutaneously. There were lower numbers of pregnancy for SubQ administration but not by much. I don't remember them reporting results based on follicles though.

good luck at your appt tomorrow!

JnAnB
iVillage Member
Registered: 09-27-2003
Wed, 04-28-2004 - 8:53am
JnAnB,

Thanks for your message!

I am confused about why the response to Gonal-F would be different from that to Follistim. Gonal-F is follitropin alfa, while Follistim is follitropin beta. My NY RE says they are "exactly the same", but there would seem to be some difference, right?

Do you know where I can find the study you mention? I did a web search but did not come up with anything of that nature. It is encouraging, in that the fact that I am doing the injections IM should be just fine.

The news from today's visit, by the way, is not good. I had one follicle Monday at 13 mm, it has only grown to 15 mm by today (it should have grown to 17 mm). There are two others at 13 mm. My husband wants to know why the RE did not increase the medication - good question! I wish I had thought of it Monday, maybe they would have done it and I would be in better shape by now.

The RE said it was up to me if I thought it was worth continuing the cycle. Well, I am certainly not going to drop any cycle even if there is a 1% chance! But I do lack confidence.

Lastly, my husband and I were discussing it, and it's on to IVF after this cycle, unless a miracle occurs and I get pg this time! I believe it would then be every other month because the ovaries have to rest in between (does anyone know for sure?)

Thanks again for your messages. Baby dust to everyone!

Lisa (42)

TTC #1 since July 2003

Injectibles cycle #4

Cycle day 15

iVillage Member
Registered: 09-27-2003
Fri, 04-30-2004 - 4:26pm
Hello everyone,

I thought I would update you:

I went back to the RE on Thursday (only one day after the previous visit, because apparently my estrogen levels (isn't it really estradiol?) looked much better. I had one follicle at 19, one at 17 and I believe three or four other smaller ones.

We did the HcG last night and we go for IUI tomorrow! This will be the first time dh will produce the stuff at the doctor's and I am nervous to have him do this in a room where others have done the same thing (!) It sort of skeeves me, the thought, and I wonder if this impacts the purity of the specimen (will it mix with any other stuff that could have spilled around - sorry, TMI - ?)

All the best and baby dust to all,

Lisa

iVillage Member
Registered: 12-26-2003
Fri, 04-30-2004 - 7:15pm
Hi Lisa,

I am glad to hear you doing better. Those follies are growing good now!!! Don't worry about DH & his sample, they will give him a sterile cup for the sample. It is kind of a strange thing we all have to go through, isn't it?

++++++++++++Tons of sticky coming your way!!!!+++++++++++++

Lisa
Lilypie Baby Days
iVillage Member
Registered: 11-30-2003
Fri, 04-30-2004 - 9:39pm
Lisa: Sending you tons!!! of baby!!! dust!!!

Hoping this is the month for you!!!

Margie

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