I don't understand?

iVillage Member
Registered: 06-16-2003
I don't understand?
13
Fri, 04-23-2004 - 1:19pm
Hello all,

I have some questions.....I am about to embark on the first cycle of injectibles (I have never tried drugs before). I just came from the RE today and they did u/s...I'm on cycle day 3, and they found 3 follicles. They said 3 eggs is all we have to work with. I thought that when I start the repronex tonite it increases eggs??? I am upset. Last month I had 6 and in Feb. I had 10 I think...? Am I to assume that this is the beginning of the end? My fsh last month was 6.2, in January it was 3. Is there hope? Maybe this is the end...so fast? Miscarriage was last summer...(and have two boys)..do I even have a chance with these drugs? (We will be doing 3 vials repronex with IUI).

I am so worried and upset.

Thanks,

Barbara

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iVillage Member
Registered: 09-27-2003
Fri, 04-23-2004 - 3:09pm
Dear Barbara,

I am not sure about this, but I don't think your RE can tell how many follicles are going to develop on cd 3. I remember the number of follicles identified grew during each of my cycles, with the progressive cycle days and days of injectibles. I really would not give up hope.

As for the FSH, again I am not an expert, but I am pretty sure that less than 10 is still considered okay. (I am sure others on this board are more versed in that subject). Also, I believe it can fluctuate.

Finally, I would encourage you to go for a second opinion if you feel there is ambiguity.

I wish you all the best and sticky baby dust!

Lisa

TTC #1 since July 2004

Injectibles cycle #4

CD 10

iVillage Member
Registered: 02-05-2004
Fri, 04-23-2004 - 3:56pm
Hi

I'm on my second cycle of injectibles. Was it your antral follicles that they were referring to? I asked my u/s tech about that when I had my last cd3 u/s. She said that they (my RE office) usually only count antral follicles for IVF pts. I've read a bit about this, and apparently antral follicles are very early follicles that may develop into follicles. However, since you've had a good number of follicles recently and your FSH is still normal, I'd just wait and see what your next u/s shows. One thing about FSH levels is that they do fluctuate quite abit, although yours are great! they don't seem to correlate with 3 early follicles although I'm not a Dr! My RE believes in monitoring FSH levels in women my age (42) so I have one drawn every month. Mine has bounced around, even went from 7.7 up to 14.4 in one month. Although, it's hovered around 9-11 the past 3 months (9.3 this month). I gave up all caffeine, I'd like to think that's helped it drop. (I wish I had your FSH levels!)

I recommend not stressing about it until you know for sure. It's your first cycle of injectibles so you have yet to see how you respond. Actually, I don't mind the injections because I feel like we're being aggressive about treatment and improving the odds for getting pg. Let me know if you have any questions about the repronex, that's what I used my first injection cycle. This cycle I'm on Gonal F because I got hold of someone's unused meds. Best of luck and keep us posted on your cycle,

God bless,

JnAnB
iVillage Member
Registered: 12-26-2003
Fri, 04-23-2004 - 6:16pm
Hi Barbara,

No that does not make any sense. There is now way of knowing how many eggs you will have to work with by day 3. Day 3 is really baseline. As a matter of fact you should not have any grown follies right now as you should have been supressed as well as this being the beginning of your cycle. They should not have an exact # for you until the eggs are retrieved and won't have a estimitate until 8-12 days into your injectibles. Something is not right here. I would talk to your RE again & make sure you didn't misunderstand. If he confirms that by day 3 he knows how many follies you will have by the end of the cycle I would seriously look for a new RE because our cycles just don't work like that. Your FSH is low for your age so yes there is a lot of hope for success.

Hope this helps.

Keep me posted.

Lisa
Lilypie Baby Days
iVillage Member
Registered: 03-15-2004
Fri, 04-23-2004 - 10:53pm
jnanb,

Does eliminating caffeine really have an effect on FSH levels? I have never heard that - please tell me more!

Barb,

Your FSH levels are beautiful. You have nothing to worry about on that score. Best of luck to you and I hope you can clear up the confusion very soon - IF is stressful enough without needless ambiguity and perplexity!!!

Take care,

Leah

iVillage Member
Registered: 03-18-2004
Sat, 04-24-2004 - 11:31am
Barb you will find that your FSH WILL flutuate from cycle to cycle however, you need also to know your E2 level as well in order to judge whether your FSH is good on a given cycle. So, hopefully your doctor is measuring both. Often women in their 40's will have fluctuating levels from cycle to cycle measured on CD3. Just because you had an FSH of 6 one cycle and now have one of 10 does not mean it is gradually going up. I had FSH levels which ranged from 5 to 23!!! over the course of TTC. It IS important that you know the corresponding E2 levels as well! It is also important that you measure FSH/E2 every CD3 and judge according to that if it is a good cycle to do meds or if you should skip it and save your $.

Antral follicle count is an indicator of how many follicles will develop in a given med cycle. Yes you SHOULD have antral follicles on CD3 and the more you have the better as it will indicate how many mature follicles you may get that cycle. With the drugs they will promote the follicles to grow and you may get additional follicles happening as well. Taking the stimulant will make your ovary work harder to grow the existing follicles so you will end up with more than one mature follicle (hopefully). One person did mention suppressants and this is sometimes used to try and slow the growth of the lead follicles while the stimulant promotes the growth of the smaller follicles. SOmetimes this protocol results in more follicles than just using stimulants alone... but not always. I think, given that this is your FIRST med cycle, it makes sense to use the stimulant by itself to see what your response is like on its own. I know some women in their 40's OVER suppress when they mix suppressants with stims. Also, IF you are doing a long protocol (doing a suppressant one cycle and then a stimulant next) you need to be guaranteed two back to back good CD3 FSH/E2 cycles which is not always a guarantee in over 40 women.

So... I think your doctor is on the right track for this cycle. It can take a few runs at it before you get the protocol which works for you. What dose are you taking and what stim are you using?

~ Pat
iVillage Member
Registered: 06-16-2003
Mon, 04-26-2004 - 7:57am
Thanks Lisa for your reply! Good luck to you on your cycle #4!

Barb

iVillage Member
Registered: 06-16-2003
Mon, 04-26-2004 - 8:04am
Hi JnAnB,

Thanks for your reply! I guess it was antral follicles?! But I am not doing IVF, just IUI w/injectibles. My last fsh was drawn at my last cycle, 1 month ago at 6.2, three months ago it was 3. I just hope that this doesn't mean they are heading upward from here and will progressively get worse. I will give up caffeine as you suggest!

Yes, I do have questions about the repronex. First I think I screwed up. I was prescribed three vials, and to mix with 1 cc of sodium chloride. I mistakenly drew up all the sodium chloride (.9, twice as much) the first two nights. Last night I took the right measure. I hope that doesn't screw me up. The injection itself wasn't painful, but I am sore afterwards. Are you? Did you have any side effects from repronex? I don't feel anything else...does that mean it is not working?

Also, after reading everyone's posts, everyone seems happy with their RE. Mine is sooooooo doom and gloom...nothing but bad news. Even with my good results/history, he has no hope and I feel he is just accomodating me...wants me to do IVF immediately (and keeps talking donor also)...this is my first time trying anything. Geeeeez.

Let me know about the Gonal F. I wish you the best of luck!!!

Barb

iVillage Member
Registered: 06-16-2003
Mon, 04-26-2004 - 8:07am
Hi Lisa,

Thanks for your reply. No, I don't think that makes any sense either...(# of follicles on CD 3). I had 10+ a couple of months ago...I hope that they do fluctuate and I can get some more....perhaps on another cycle. With three follicles I wonder if it is even worth trying the injectibles this month.

I just replied back to JnAnB and explained this RE's attitude....

Thanks,

Barb

iVillage Member
Registered: 06-16-2003
Mon, 04-26-2004 - 8:12am
Hi Pat,

Thanks for your reply and your encouraging words..I hope it my FSH is just fluctuating... it was 3 in January and 6.2 last month in March. This present cycle I am on CD6, they didn't measure it the other day. But they only see 3 follicles on CD3. They still wanted to proceed with the injectibles cycle. I didnt' take suppressants and they didn't mention this to me? I am taking three vials of repronex....and then pregnyl for trigger? (Still new to me)..

Thanks,

Barb

iVillage Member
Registered: 06-16-2003
Mon, 04-26-2004 - 8:13am
Thanks Leah!

Barb

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