I thought his "We've come too far to turn back now." line wasn't quite as passionate or motivational as the "Yes, we can." of his campaign in '08, but I like the underlying message.
I like his message about insourcing and rewarding companies who manufacture here in the US. As an environmentalist, I wasn't too keen on his push to open up 75% of the available off-shore drilling resources and found it ironic when he mentioned the BP oil spill just a few minutes later.
You can find a recap here if you didn't get to watch~
And the full speech here~