Fructo-oligosaccharides (FOS) and Other Oligosaccharides

 
Fructo-oligosaccharides (FOS) and Other Oligosaccharides

The term “oligosaccharide” refers to a short chain of sugar molecules (“oligo” means “few” and “saccharide” means “sugar.”) Fructo-oligosaccharides (FOS) and inulin, which are found in many vegetables, consist of short chains of fructose molecules. Galacto-oligosaccharides (GOS), which also occur naturally, consist of short chains of galactose molecules. These compounds can be only partially digested by humans. When oligosaccharides are consumed, the undigested portion serves as food for “friendly” bacteria, such as Bifidobacteria and Lactobacillus species.

What Are "Star" Ratings?

a7_3star Reliable and relatively consistent scientific data showing a substantial health benefit.

a7_2star Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

a7_1star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:


Used for AmountWhy
Eczema in Infants
(Galacto-oligosaccharides)
90% galacto-oligosaccharides and 10% fructo-oligosaccharides mixture added daily to infant formula 2 stars In one study, adding a mixture of 90% galacto-oligosaccharides and 10% fructo-oligosaccharides to infant formula prevented the development of eczema in babies who were at high risk of developing eczema.

2 stars Eczema in Infants

90% galacto-oligosaccharides and 10% fructo-oligosaccharides mixture added daily to infant formula

In a double-blind trial, the addition of a mixture of 90% galacto-oligosaccharides and 10% fructo-oligosaccharides to infant formula prevented the development of eczema in infants who were at high risk of developing eczema. The incidence of eczema in the first six months of life was 9.8% in the group receiving oligosaccharides, compared with 23.1% in the placebo group, a statistically significant difference. The product used in this study was designed to mimic the oligosaccharide content of human milk, and was added at a concentration of 0.8 grams per 100 ml.5


Used for AmountWhy
High Triglycerides
8 to 20 grams daily2 stars Several trials have shown that FOS supplementation lowers triglycerides in people with elevated levels.

2 stars High Triglycerides

8 to 20 grams daily

Several double-blind trials have evaluated the efficacy of fructo-oligosaccharides (FOS) or inulin (a related compound) for lowering blood cholesterol and triglyceride levels. These trials have shown that in individuals with elevated total cholesterol or triglyceride levels, including people with type 2 diabetes, FOS or inulin (in amounts ranging from 8 to 20 grams daily) produced significant reductions in triglyceride levels; however, the effect on cholesterol levels was inconsistent.6 , 7 , 8 , 9 In people with normal or low cholesterol or triglyceride levels, FOS or inulin produced little effect.10 , 11 , 12


Used for AmountWhy
Indigestion, Heartburn, and Low Stomach Acidity
5 grams per day 1 star Supplementing with fructo-oligosaccharides may help relieve abdominal discomfort, fullness, constipation, urgency, and diarrhea.

1 star Indigestion, Heartburn, and Low Stomach Acidity

5 grams per day

In a double-blind trial, supplementation with 5 grams of fructo-oligosaccharides per day for six weeks was significantly more effective than a placebo at relieving symptoms of dyspepsia such as such as abdominal discomfort, fullness, constipation, urgency, and diarrhea. The average symptom severity decreased by 44% in the group receiving fructo-oligosaccharides.13

Used for AmountWhy
Pre- and Post-Surgery Health
Refer to label instructions 1 star Supplementing with fructo-oligosaccharides (FOS) appears to improve iron absorption and restore iron levels, which may be reduced after surgery.

1 star Pre- and Post-Surgery Health

One preliminary study found iron levels to be reduced after both minor and major surgeries, and iron supplementation prior to surgery was not able to prevent this reduction.14 A controlled trial found that intravenous iron was more effective than oral iron for restoring normal iron levels after spinal surgery in children.15 One animal study reported that supplementation with fructo-oligosaccharides (FOS) improved the absorption of iron and prevented anemia after surgery,16 but no human trials have been done to confirm this finding. Some researchers speculate that iron deficiency after a trauma such as surgery is an important mechanism for avoiding infection, and they suggest that iron supplements should not be given after surgery.17


Used for AmountWhy
Type 2 Diabetes
Refer to label instructions 1 star In one trial, supplementing with fructo-oligosaccharides significantly lowered fasting blood-sugar levels and serum total-cholesterol levels in people with type 2 diabetes.

1 star Type 2 Diabetes

In a preliminary trial, supplementation with fructo-oligosaccharides (FOS) (8 grams per day for two weeks) significantly lowered fasting blood-sugar levels and serum total-cholesterol levels in people with type 2 diabetes.18 However, in another trial, supplementing with FOS (15 grams per day) for 20 days had no effect on blood-glucose or lipid levels in people with type 2 diabetes.19 In addition, some double-blind trials showed that supplementing with FOS or galacto-oligosaccharides (GOS) for eight weeks had no effect on blood-sugar levels, insulin secretion, or blood lipids in healthy people.20 , 21 Because of these conflicting results, more research is needed to determine the effect of FOS on diabetes and lipid levels.
Also indexed as:
  • oligosaccharides

About this treatment

How to Use It

The average daily intake of oligosaccharides by people in the United States is estimated to be about 800 to 1,000 mg. For the promotion of healthy bacterial flora, the usual recommendation for FOS, GOS, or inulin is 2,000 to 3,000 mg per day with meals. In the studies on diabetes and high blood lipids (cholesterol and triglycerides), amounts ranged from 8 to 20 grams per day.

Where to Find It

FOS and inulin are found naturally in Jerusalem artichoke, burdock, chicory, leeks, onions, and asparagus. FOS products derived from chicory root contain significant quantities of inulin, a fiber widely distributed in fruits, vegetables and plants, which is classified as a food ingredient (not as an additive) and is considered to be safe to eat. In fact, inulin is a significant part of the daily diet of most of the world’s population. FOS can also be synthesized by enzymes of the fungus Apergillus niger acting on sucrose. GOS is naturally found in soybeans and can be synthesized from lactose (milk sugar). FOS, GOS, and inulin are available as nutritional supplements in capsules, tablets, and as a powder.

Possible Deficiencies

As FOS, GOS, and inulin are not essential nutrients, no deficiency state exists.


Last Review: 05-11-2011

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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