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Cast: John Cusack, Steve Buscemi, John Cleese, Sean Hayes, Molly Shannon and Eddie Izzard
Release date: September 19
Why you should see it: The charming 'toon tells the story of hunchbacked Igor (Cusack), a scientist's assistant who's tired of being second banana. Igor's plan: to win the Evil Science Fair with an invention of his own.
Box office bottom line: It's a story that combines a look at the world of mad scientists with a tale about an endearing underdog, plus smart touches like a character named Dr. Schadenfreude (Izzard). It could be a surprise fall hit.