Jennifer Aniston & Demi Moore Tackle Breast Cancer in 'Five'

The actresses step behind the camera to direct segments of the anthology film Five, premiering Oct. 10 at 9 p.m. ET on Lifetime

What do Jennifer Aniston, Alicia Keys and Demi Moore have in common with Patricia Clarkson, Jeanne Tripplehorn, Rosario Dawson and Ginnifer Goodwin? Together, they have created Five, an anthology of five intertwined short films that is the Lifetime Channel's contribution to Breast Cancer Awareness Month.

Premiering Monday, Oct. 10, at 9 p.m. ET on Lifetime, Five tells five overlapping stories about women dealing with breast cancer. The storylines are all tied together by recurring characted Pearl (Tripplehorn), who dedicates her life to fighting breast cancer after her mother succumbs to the disease. Pearl becomes an oncologist who treats other characters, including stripper Cheyanne (Lyndsey Fonseca), career-driven Lili (Dawson) and survivor Mia (Clarkson).

One of the exciting aspects about the film is that it showcases the directing talents of some of Hollywood's best known leading ladies as they step behind the camera. Moore, 48, directed Five's first segment, Charlotte, which takes place during the moon landing of 1969 and stars Goodwin as Pearl's cancer-diagnosed mother Charlotte and Ava Acres as a young Pearl. Keys, 30, directed Lili, featuring Dawson as a career woman struggling to break the news of her cancer diagnosis to her mother. And Aniston, 42, directed Mia, which stars Clarkson as a breast cancer survivor -- and is being heralded as the best of the five films.

The anthology's other two short films are directed by women with a bit more experience behind the lens. Wayne's World director Penelope Spheeris, 65, helmed the segment Cheyanne, which follows the titular stripper as she grapples with what a mastectomy could mean for her career. And 40-year-old Monster director Patty Jenkins -- who recently received an Emmy nod for directing the pilot of The Killing -- had the driver's seat for Pearl, which finds Tripplehorn's oncologist learning that she has breat cancer.

The women involved in the movie are making a point to take an active stance on breast cancer awareness. Last Monday, Aniston headed to Washington, D.C., to attend Breast Cancer Awareness Month events. First she joined Jill Biden to tour the new Inova Breast Cancer Center in Alexandria, Va., and then she attended a screening and reception for Five at the Ronald Reagan Building.

After tonight's premiere, Five will also air Tuesday, Oct. 11 at 1 a.m. ET, and Saturday, Oct. 15 at 8 p.m. ET, on Lifetime. Watch the trailer below.

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