Are Katherine Heigl & T.R. Knight Leaving Grey's?

This is a big deal, Grey's Anatomy fans! It looks like Izzie and George could be making their exits from the medical drama before we know it.

Grey's star James Pickens Jr. confirmed to UsMagazine.com that Katherine Heigl and T.R. Knight are, indeed, saying farewell to the series.

"Yes, she is," James told the mag, when asked if Kat was on her way out. "Wherever Katherine goes, I wish her nothing but the best."

And Kat's BFF is right behind her. "He's going too," James revealed. "He just wanted to pursue other career paths."

The network and studio say they cannot confirm anything, and both stars' reps have declined to comment.

BUT an ABC source tells E!, "There's no way [Pickens] could know that, because nothing has been decided yet. Nothing has been written and [Heigl and Knight] are still working out what will happen next season with the network."

So, you Gizzie lovers still have some hope -- but it's a very, very small glimmer.

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