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Metformin (Glucophage) for polycystic ovary syndrome
The most common side effects of metformin are:
- Nausea.
- Loss of appetite.
- Diarrhea.
- Increased abdominal gas.
- A metallic taste.
These side effects occur 20% to 30% of the time. Side effects usually decrease over time. The dosage of metformin is usually increased gradually to prevent these possible side effects.3
Blood levels of vitamin B12 can decrease in women who take this medicine, but the lower level usually does not cause health problems. Doctors do recommend that women on metformin take a daily multiple vitamin supplement.
A rare side effect of taking metformin is a condition called lactic acidosis. This happens when metformin builds up in the blood instead of being removed by the kidneys. If not treated, this acid buildup can lead to coma and death.
Metformin should not be used by women who:
- Are dehydrated from not eating or drinking, or from having a fever.
- Are about to have a surgical procedure or an X-ray with contrast dye.
- Have kidney or liver problems.
- Drink excessive amounts of alcohol.
The use of metformin during pregnancy is not well researched. So if you are pregnant or are trying to get pregnant, be sure to talk with your doctor about what is best for you.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
| By: | Healthwise Staff | Last Revised: January 28, 2010 |
| Medical Review: | Sarah Anne Marshall, MD - Family Medicine Kirtly Jones, MD - Obstetrics and Gynecology | |
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