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Metoclopramide
Summary of Interactions with Vitamins, Herbs, & Foods
 May Be Beneficial: Depletion or interference—This medication may deplete these substances from the body or interfere with how they work; extra intake may help replenish them. | none |
| May Be Beneficial: Side effect reduction and/or prevention—These substances may help reduce the likelihood and/or severity of a potential side effect caused by the medication.
| none |
| May Be Beneficial: Supportive interaction—These substances may help this medication work better. | White Willow* |
 Avoid: Reduces drug effectiveness—When taking this medication, avoid these substances as they may decrease the medication's absorption and/or activity in the body. | none |
| Avoid: Adverse interaction—When taking this medication, avoid these substances, as the combination may cause undesirable or dangerous interactions. | N-Acetyl Cysteine* |
 Check: Explanation needed—When taking this medication, read the article details and discuss them with your doctor or pharmacist before taking these substances. | none |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Also indexed as:
- metoclopramide,
- metoclopramide HCl,
- metoclopramide hydrochloride,
- Octamide,
- Reglan
About this treatment
Interactions with Vitamins
N-acetyl cysteine
A single case report described a 15-year-old girl who suffered oxygen deprivation in her body tissues after being given high amounts of metoclopramide and N-acetyl-cysteine to treat her for an overdose of acetaminophen. It is unknown whether N-acetyl-cysteine supplementation in the absence of acetaminophen overdose could cause similar effects in people taking metoclopramide. Until controlled research determines the safety of this combination, it should be used only under the supervision of a qualified physician.
Interactions with Herbs
Willow (Salix alba)
Salicylic acid is a compound formed in the body from either aspirin or willow bark. Taking metoclopramide before aspirin or willow bark results in higher concentrations of salicylic acid and greater pain relief in people suffering from an acute migraine headache. Controlled studies are necessary to confirm the benefit of this interaction.
Interaction with Foods and Other Compounds –––
Lactose-containing foods
Individuals who have lactose intolerance (difficulty digesting milk sugar) may experience more severe symptoms while taking metoclopramide. Lactose is the milk sugar present in dairy products.
Caffeine
A single case report described a 42-year-old man taking metoclopramide who experienced mental depression after he abruptly quit using caffeine. People who are advised to quit caffeine should probably reduce their coffee or tea consumption gradually if they are taking metoclopramide.
Alcohol
Drinking alcohol while taking metoclopramide may significantly increase the amount and speed of alcohol absorption, resulting in enhanced alcohol effects such as drowsiness. Consequently, people taking metoclopramide should avoid alcohol, especially when staying alert is necessary.
Last Review: 05-11-2011
Copyright © 2011 Aisle7. All rights reserved. www.Aisle7.net
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
Learn more about Aisle7, the company.
The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.
© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
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