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Nefazodone
Nefazodone is a drug used to treat people with depression.
Summary of Interactions with Vitamins, Herbs, & Foods
 May Be Beneficial: Depletion or interference—This medication may deplete these substances from the body or interfere with how they work; extra intake may help replenish them. | none |
| May Be Beneficial: Side effect reduction and/or prevention—These substances may help reduce the likelihood and/or severity of a potential side effect caused by the medication.
| none |
| May Be Beneficial: Supportive interaction—These substances may help this medication work better. | none |
 Avoid: Reduces drug effectiveness—When taking this medication, avoid these substances as they may decrease the medication's absorption and/or activity in the body. | none |
| Avoid: Adverse interaction—When taking this medication, avoid these substances, as the combination may cause undesirable or dangerous interactions. | St. John’s Wort* |
 Check: Explanation needed—When taking this medication, read the article details and discuss them with your doctor or pharmacist before taking these substances. | none |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Also indexed as:
- nefazodone,
- Serzone
About this treatment
Interactions with Herbs
Digitalis (Digitalis lanata, Digitalis purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.
Nefazodone increased serum digoxin levels in a three-way crossover study of 18 healthy men. No interactions between nefazodone and digitalis have been reported. Until more is known, nefazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.
St. John’s wort (Hypericum perforatum)
Although there have been no interactions reported in the medical literature, it is best to avoid using nefazodone with St. John’s wort unless you are under the supervision of a qualified healthcare professional.
Interactions with Foods & Other Compounds
Food
Nefazodone may be taken with or without food.
Alcohol
People taking nefazodone are advised to avoid alcohol.
Last Review: 05-11-2011
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Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The Aisle7 knowledgebase does not contain every possible interaction.
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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.
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