Designed to treat mild to moderate pain, OTC nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen and aspirin can dissipate fever, headaches, menstrual cramps, arthritis and the pain and inflammation from sports and other injuries. (Avoid them if you are pregnant or nursing or have heart disease.) They also can cause gastrointestinal problems like bleeding in the stomach and fluid retention, says Jack Fincham, Ph.D., R.Ph., a professor of pharmacy practice and administration at the University of Missouri, Kansas City. The risk of stomach bleeding rises if you have more than three alcoholic drinks a day, says Fincham. If that’s the case don’t use NSAIDs at all, he advises.