Pantothenic Acid

 
Pantothenic Acid

Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in the Kreb’s cycle of energy production and is needed to make the neurotransmitter acetylcholine. It is also essential in producing, transporting, and releasing energy from fats. Synthesis of cholesterol (needed to manufacture vitamin D and steroid hormones) depends on pantothenic acid. Pantothenic acid also activates the adrenal glands. Pantethine—a byproduct of pantothenic acid—has been reported to lower blood levels of cholesterol and triglycerides.

What Are "Star" Ratings?

a7_3star Reliable and relatively consistent scientific data showing a substantial health benefit.

a7_2star Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

a7_1star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:


Used for AmountWhy
High Cholesterol
300 mg pantethine taken two to four times per day3 stars Pantethine, a byproduct of vitamin B5 (pantothenic acid), may help reduce the amount of cholesterol made by the body.

3 stars High Cholesterol

300 mg pantethine taken two to four times per day

Pantethine, a byproduct of vitamin B5 (pantothenic acid), may help reduce the amount of cholesterol made by the body. Several preliminary2, 3, 4, 5, 6 and two controlled7, 8 trials have found that pantethine (300 mg taken two to four times per day) significantly lowers serum cholesterol levels and may also increase HDL. However, one double-blind trial in people whose high blood cholesterol did not change with diet and drug therapy, found that pantethine was also not effective.9 Common pantothenic acid has not been reported to have any effect on high blood cholesterol.

Used for AmountWhy
High Triglycerides
300 mg pantethine three times per day3 stars Pantethine, a byproduct of pantothenic acid (vitamin B5), has been shown to lower triglyceride levels in several clinical trials.

3 stars High Triglycerides

300 mg pantethine three times per day

Pantethine is a byproduct of pantothenic acid (vitamin B5). Several clinical trials have shown that 300 mg of pantethine taken three times per day will lower TG levels.10, 11, 12 Pantothenic acid, which is found in most B vitamins, does not have this effect.


Used for AmountWhy
Rheumatoid Arthritis
2,000 mg daily2 stars People with rheumatoid arthritis may be partially deficient in pantothenic acid. In one trial, taking pantothenic acid resulted in less morning stiffness, disability, and pain.

2 stars Rheumatoid Arthritis

2,000 mg daily

Research suggests that people with RA may be partially deficient in pantothenic acid (vitamin B5).13 In one placebo-controlled trial, those with RA had less morning stiffness, disability, and pain when they took 2,000 mg of pantothenic acid per day for two months.14


Used for AmountWhy
Acne Vulgaris
Refer to label instructions 1 star In a preliminary trial, taking panthothenic acid supplements and applying a topical cream improved moderate acne in two months and severe acne within six months.

1 star Acne Vulgaris

In a preliminary trial, people with acne were given 2.5 grams of pantothenic acid orally four times per day, for a total of 10 grams per day—a remarkably high amount.15 A cream containing 20% pantothenic acid was also applied topically four to six times per day. With moderate acne, near-complete relief was seen within two months, while severe conditions took at least six months to respond. Eventually, the intake of pantothenic acid was reduced to 1 to 5 grams per day—still a very high amount.

Also indexed as:
  • pantothenate,
  • pantothenic acid,
  • vitamin B5,
  • vitamin B-5

About this treatment

How to Use It

Most people do not need to supplement with pantothenic acid. However, the 10–25 mg found in many multivitamin supplements might improve pantothenic acid status. So-called primitive human diets provided greater amounts of this nutrient than is found in modern diets. Most cholesterol researchers using pantethine have given people 300 mg three times per day (total 900 mg).

Where to Find It

Liver, yeast, and salmon have high concentrations of pantothenic acid, but most other foods, including vegetables, dairy, eggs, grains, and meat, also provide some pantothenic acid.

Possible Deficiencies

Pantothenic acid deficiencies may occur in people with alcoholism but are generally believed to be rare.


Last Review: 05-11-2011

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

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