Progesterone - Side Effects

 
Progesterone

Progesterone is a hormone from a corpus luteum, formed by the cyclical rupture of an ovarian follicle. Progesterone is necessary for proper uterine and breast development and function.

What Are "Star" Ratings?

a7_3star Reliable and relatively consistent scientific data showing a substantial health benefit.

a7_2star Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

a7_1star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

This supplement has been used in connection with the following health conditions:


Used for AmountWhy
Amenorrhea
Consult a qualified healthcare practitioner2 stars The oral, micronized form has been shown to successfully induce normal menstrual bleeding in women with secondary amenorrhea. (Use of this natural hormone should always be supervised by a doctor.)

2 stars Amenorrhea

Consult a qualified healthcare practitioner

Oral, micronized progesterone (200 to300 mg per day) has been shown in at least one double-blind trial to successfully induce normal menstrual bleeding in women with secondary amenorrhea.1 Use of this natural hormone should always be supervised by a doctor.


Used for AmountWhy
Menopause
Apply enough topical cream to provide 20 mg of the supplement to the skin daily2 stars Progesterone, either natural or synthetic, has been linked to improved hot flashes, anxiety, depression, sleep problems, and sexual functioning, and quality of life.

2 stars Menopause

Apply enough topical cream to provide 20 mg of the supplement to the skin daily

Natural progesterone supplementation has been anecdotally linked to reduction in symptoms of menopause.2 , 3 , 4 In one trial, natural progesterone was found to have no independent effect on symptoms, and synthetic progestins were found to increase breast tenderness.5 However, a double-blind trial found that topical administration of natural progesterone cream led to a reduction in hot flashes in 83% of women, compared with improvement in only 19% of those given placebo.6 Preliminary research has found that oral, micronized progesterone therapy is associated with improved quality of life among postmenopausal women. However, oral micronized progesterone is available only by prescription in the United States.7 Hot flashes, anxiety, depression, sleep problems, and sexual functioning were among the symptoms improved in a majority of women surveyed. Synthetic progestins, also available only by prescription, have reduced symptoms of menopause.8 , 9 , 10

Progesterone is a hormone and, as such, concerns about its inappropriate use (i.e., as an over-the-counter supplement) have been raised. The amount of progesterone in commercially available creams varies widely, and the progesterone content is not listed on the label because the creams are legally regulated as cosmetics, not dietary supplements. Therefore, a physician should be consulted before using these hormone-containing creams as supplements. Although few side effects have been associated with topical progesterone creams, skin reactions may occur in some users. Effects of natural progesterone on breast cancer risk remain unclear; research has suggested both increased and reduced risk.


Used for AmountWhy
Osteoporosis
Consult a qualified healthcare practitioner2 stars Preliminary evidence suggests that progesterone might reduce osteoporosis risk by promoting bone density.

2 stars Osteoporosis

Consult a qualified healthcare practitioner

Preliminary evidence suggests that progesterone might reduce the risk of osteoporosis.11 A preliminary trial using topically applied natural progesterone cream in combination with dietary changes, exercise, vitamin and calcium supplementation, and estrogen therapy reported large gains in bone density over a three-year period in a small group of postmenopausal women, but no comparison was made to examine the effect of using the same protocol without progesterone.12 Other trials have reported that adding natural progesterone to estrogen therapy did not improve the bone-sparing effects of estrogen and that progesterone applied topically every day for a year did not reduce bone loss.13 14 In a more recent double-blind study, however, progesterone had a modest bone-sparing effect in post-menopausal women.15

Used for AmountWhy
Dysmenorrhea
Refer to label instructions 1 star Some practitioners report success using topical progesterone cream for dysmenorrhea.

1 star Dysmenorrhea

Some practitioners report success using topical progesterone cream for dysmenorrhea.16 To date, this approach lacks sufficient research.


Used for AmountWhy
Premenstrual Syndrome
Refer to label instructions 1 star Anecdotal reports suggest that progesterone may be effective against PMS symptoms.

1 star Premenstrual Syndrome

Most well-controlled trials have not found vaginally applied natural progesterone to be effective against the symptoms of premenstrual syndrome.17 Only anecdotal reports have claimed that orally or rectally administered progesterone may be effective.18 Progesterone is a hormone, and as such, there are concerns about its inappropriate use. A physician should be consulted before using this or other hormones. Few side effects have been associated with use of topical progesterone creams, but skin reactions may occur. The effect of natural progesterone on breast cancer risk remains unclear; some research suggests the possibility of increased risk, whereas other research points to a possible reduction in risk.

Also indexed as:
  • progesterone

About this treatment

Side Effects

Progesterone is a hormone and, as such, concerns about its inappropriate use have been raised. A physician should be consulted before using this hormone as a supplement. Few side effects have been associated with topical progesterone creams but can include skin reactions. Effects of natural progesterone on breast cancer risk remain unclear. Research has suggested both increased and reduced risk.

Synthetic progestins have many well-known side effects, including the increase of LDL (“bad”) cholesterol and the decrease of HDL (“good”) cholesterol. Other side effects reported with synthetic progestins include bloating, breast soreness, depression, and mood swings. Natural progesterone has been shown to have no adverse effect on HDL cholesterol levels. Overall, natural progesterone is considerably safer than progestins and is therefore preferred by many doctors in situations where either would be effective.


Last Review: 05-11-2011

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

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