Prozac and breastfeeding

I'm wondering if you can provide some journal article references on prozac use during breastfeeding.


Debbi Donovan

Debbi Donovan is a Board Certified Lactation Consultant, as well as a retired La Leche League Leader. For more than a decade, Debbi... Read more

Here are the four references I am aware of that refer to the use of Prozac (fluoxetine) while breastfeeding:

  • Wisner K. et al. Antidepressant treatment during breast-feeding. Am J Psychiatry 153(9): 1132-37, 1996.
  • Taddio A. et al. Excretion of fluoxetine and its metabolite in human breast milk. Pediatric Res 35 (4, part 2): 149a, 1994. Abstract.
  • Burch K. et al. Fluoxetine/Norfluoxetine concentrations in human milk. Pediatrics 89:676, 1992.
  • Isenberg K. Exceretion of fluoxetine in human breast milk. J Clin Psychiatry 51:169, 1990.

In an article in the March 1997 "Clinical Issues in Lactation", Thomas Hale, R.Ph., Ph.D., discussed antidepressants and breastfeeding, and stated, "At this time using the data provided in the literature, it would seem prudent to avoid Prozac and instead use Zoloft although this is based on preliminary data that is somewhat premature."

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