Talk with your gynecologist, though most of the time it’s actually our minds that get in the way of a fabulous finale, says Cooper. However, there may an underlying health condition or medication you’re taking that’s interfering with your good time. For instance, the clogged arteries that come with heart disease can restrict blood flow to the tiny blood vessels in your genitals; diabetes can blunt nerve endings. Hormone-based contraceptives, which lower testosterone, can also dull sexual sensation while antihistamines often dry up your natural vaginal lubricants, making sex uncomfortable. Selective serotonin reuptake inhibitor antidepressants (SSRIs) and meds for anxiety and hypertension are also notorious for depressing the libido so you’re not even interested in sex, let alone orgasm.