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Dates: 1994 (ABC) 1995-1999 (WB)
Episodes: 120
Why We Miss It: It was a clever, light and funny show about twins who were separated at birth and accidentally reunited at a mall 14 years later. Tia and Tamera Mowry played the roles with ease, and it was amusing to see that neither of the girls was afraid to act foolish on television in order to get a good laugh. The twins, along with Tia's adopted mother on the show, Jackee Harry, went on to win two Image Awards, and Sister, Sister was the first WB show to achieve the 100-episode mark.