Consult with your physician about whether you should take medications to help you quit. Nicotine is physiologically addictive. Many smokers develop tolerance and withdrawal, and need medications to help them cope with the physiological cravings that happen when they stop. Medications for stopping smoking include some antidepressants, drugs that block the nicotine receptors in the brain and nicotine replacement products such as nicotine gum, patches and lozenges that contain varying doses of nicotine to wean you off of the drug gradually, minimizing cravings. Some medications need to be started before you quit, while others should be started the day you stop smoking. “For people concerned about weight gain when they quit smoking, staying on the patch and an antismoking drug for as long as six months seems to be really helpful,” Sokolove says.