PHOTOS: Oprah Winfrey's 25 Most Memorable Moments

As the daytime TV queen's talk show comes to an end after 25 seasons, relive her most talked-about moments (26 Photos)

Donna Kaufman on May 23, 2011 at 12:53AM

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PHOTOS: Oprah Winfrey's 25 Most Memorable Moments

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Tom Cruise Jumps on the Couch (2005)

When Tom Cruise and Katie Holmes first announced their love to the world in 2005, no one knew what to make of their sudden romance. A month later, Cruise appeared on The Oprah Winfrey Show and showed us all that he was either totally in love -- or completely insane. Jumping around the set, falling to his knees, pumping his fist, the actor even grabbing Oprah by both hands and shook her. "What has HAPPENED to you?" asked the baffled, wide-eyed host. "I'm love," Cruise responded, before leaping up and down on Oprah's couch like a kid on a sugar high. "This boy is GONE," Oprah declared incredulously. As it became clear that Cruise wasn't interested in her War of the Worlds questions, Oprah brought Holmes out in front of the cameras for a televised lip lock with her future husband.

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