The Food and Drug Administration has approved three medications for treating fibromyalgia: Pregabalin (Lyrica), duloxetine (Cymbalta), and milnacipran (Savella). Duloxetine and milnacipran both raise the levels of certain brain chemicals to lessen the transmission of pain signals and improve mood. Pregabalin works by blocking the overactivity of nerve cells. Another drug, gabapentin (Neurontin), while approved for treating restless leg syndrome rather than fibromyalgia, is sometimes prescribed by doctors “off label” for fibromyalgia; it works similarly to Lyrica. For some people over-the-counter painkillers such as acetaminophen (Tylenol) or ibuprofen or other non-steroidal antiinflammatory drugs (NSAIDs) can also help. There’s also new research that topical products that contain capsaicin (the substance in chili peppers that makes them taste hot) can bring at least short term relief for fibromyalgia pain and make people feel better overall.