Trying to conceive: Is Metrodin safe while nursing?

I am the mom of two beautiful children. My nine month old was conceived after a long battle with infertility. I am still breastfeeding her and would really hate to wean at this time. I would like to get pregnant again, but would have to resort to fertility drugs (probably metrodin) and IUI (intrauterine insemination) once again. Any possibility of working towards pregnancy and not weaning -- at least not completely? Is it safe to use metrodin while nursing?

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Debbi Donovan

Debbi Donovan is a Board Certified Lactation Consultant, as well as a retired La Leche League Leader. For more than a decade, Debbi... Read more

It's great to hear that you want to continue nursing while working towards pregnancy. You may find it more difficult to become pregnant while breastfeeding, depending on the amount of time your little one still spends at your breast. In general, the more your baby breastfeeds, and the shorter the interval between feeds, the greater the likelihood that her nursing will suppress ovulation. For some women, even occasional nursing is enough to cause an altered menstrual cycle, in which not enough progesterone is produced to sustain a fertilized ovum. Of course, it's impossible for me to predict if this will be the case in your situation, especially with the use of Metrodin to increase fertility.

Metrodin (urofollitropin) is a fertility drug. It is . identical to the follicle stimulating hormone (FSH) that is naturally produced by the pituitary gland. Metrodin is often prescribed for women who have low levels of FSH and too-high levels of LH (luteinizing hormone).

Metrodin is commonly used along with human chorionic gonadotropin (hCG), which stimulates the natural LH surge, causing ovulation to occur. I do not know if frequent breastfeeding would have an undesirable impact on fertility when using these medications. It would be wise to discuss this with your Health Care Provider.

It is not known if Metrodin is secreted into human milk, though it is very unlikely, due to its high molecular weight (34,000). "Further, it would be largely destroyed in the infant's stomach and oral absorption by the infant would be extremely unlikely" (Medications and Mothers' Milk, Thomas Hale, R.Ph., Ph.D., 1997).

Best wishes in mothering!

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