Attenuate the guilt
You don't have to be a student of Sun Tzu's The Art of War to understand that diversionary tactics can be of great assistance. It can be kind of cheesy, but buying her presents is a good way to have her ease the pressure. Or if you suspect that your lady feels neglected, schedule "date night" on an evening that you're not with your boys. The idea is to counterbalance. You will get pleasure from your night, so find a way to bring her pleasure. If gifts and special treatment can make her feel better, hey, who am I to judge?
Similarly, you can select a date for boys' night when you know she will be busy. Not necessarily because she won't notice your absence, but because it won't leave her feeling like an outsider. Better yet, suggest that she organize a girls' night out. If she's friends with the wives and girlfriends of your mates, it could be a fantastic opportunity for the genders to go their separate ways.