Wound Healing - Supplements

Repair the damage to your skin and other soft tissues by caring for affected areas and focusing on your overall health. According to research or other evidence, the following self-care steps may be helpful.

Deal with deficiencies
Stick to a healthy diet and take a multivitamin to prevent deficiencies that can slow wound healing
Get support from vitamin C
Take at least 1,000 mg a day of vitamin C to promote connective tissue repair
Try on topicals
Apply an ointment containing zinc, chondroitin sulfate, and/or gotu kola to speed healing of skin wounds
Discover the benefits of bromelain
To reduce swelling and speed the healing time for surgical wounds and soft tissue injuries, take several hundred milligrams a day of this pineapple-derived enzyme during the first several days after surgery or injury

Also indexed as:

cleaning wounds,
first aid,
wound care,
wound cleaning

About this treatment

What Are "Star" Ratings?

a7_3star Reliable and relatively consistent scientific data showing a substantial health benefit.

a7_2star Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

a7_1star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

Supplement	Amount	Why
Bromelain	3,000 MCU (2,000 GDU) three times per day for several days, followed by 2,000 MCU three times per day	Taking bromelain may help reduce swelling and speed the healing time for surgical wounds and soft tissue injuries.
Bromelain 3,000 MCU (2,000 GDU) three times per day for several days, followed by 2,000 MCU three times per day Supplementation with bromelain, an enzyme derived from pineapple stem, prior to and following a surgical procedure has been shown to reduce swelling, bruising, healing time, and pain.³ Bromelain supplementation has also been shown to accelerate the healing of soft-tissue injuries in male boxers.⁴ The amount of bromelain used in these studies was 40 mg four times per day, in the form of enteric-coated tablets. Enteric-coating prevents the stomach acid from partially destroying the bromelain. Most currently available bromelain products are not enteric-coated, and it is not known if such products would be as effective as enteric-coated bromelain. What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Vitamin B-Complex	Follow label directions	Thiamine (vitamin B1), pantothenic acid (vitamin B5), and other B vitamins have all been shown to play a role in wound healing. For this reason, some healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing.
Vitamin B-Complex Follow label directions Thiamine (vitamin B1),⁵pantothenic acid (vitamin B5),⁶ and other B vitamins⁷ have all been shown to play a role in wound healing in animal studies. For this reason, although human research is lacking, some alternative healthcare practitioners recommend a high-potency B vitamin supplement to promote wound healing. What Else Is This Supplement Used For?

Supplement	Amount	Why
Vitamin C	1 to 3 grams daily	Taking vitamin C may promote connective tissue repair.
Vitamin C 1 to 3 grams daily Vitamin C is needed to make collagen (connective tissue) that strengthens skin, muscles, and blood vessels and to ensure proper wound healing. Severe injury appears to increase vitamin C requirements,⁸ and vitamin C deficiency causes delayed healing.⁹ Preliminary human studies suggest that vitamin C supplementation in non-deficient people can speed healing of various types of wounds and trauma, including surgery, minor injuries, herniated intervertebral discs, and skin ulcers.¹⁰^{, 11} A combination of 1–3 grams per day of vitamin C and 200–900 mg per day of pantothenic acid has produced minor improvements in the strength of healing skin tissue.¹²^{, 13} What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Zinc	30 mg daily (with 2 mg copper daily to prevent depletion), or apply topical zinc preparations regularly	Zinc is a component of enzymes needed to repair wounds, and even a mild deficiency can interfere with optimal recovery from everyday tissue damage.
Zinc 30 mg daily (with 2 mg copper daily to prevent depletion), or apply topical zinc preparations regularly Zinc is a component of many enzymes, including some that are needed to repair wounds. Even a mild deficiency of zinc can interfere with optimal recovery from everyday tissue damage, as well as from more serious trauma.¹⁴^{, 15} One controlled trial found the healing time of a surgical wound was reduced by 43% with oral supplementation of 50 mg of zinc three times per day, in the form of zinc sulfate.¹⁶ Whether oral zinc helps tissue healing when no actual zinc deficiency exists is unclear,¹⁷ but doctors often recommend 30 mg of zinc per day for four to six weeks to aid in the healing of wounds. Topical zinc-containing treatments, on the other hand, have improved healing of skin wounds even when there is no deficiency.¹⁸ ^{, 19} Long-term oral zinc supplementation must be accompanied by copper supplementation to prevent a zinc-induced copper deficiency. Typically, if 30 mg of zinc are taken each day, it should be accompanied by 2 mg of copper. If 60 mg of zinc are used, it should be accompanied by 3 mg of copper each day. What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Aloe	Apply stabilized gel three to five times daily	Aloe has been shown to decrease inflammation, promote cellular repair, and facilitate wound healing.
Aloe Apply stabilized gel three to five times daily In animal studies of skin inflammation, both topical and oral aloe vera have proven beneficial in decreasing inflammation and promoting cellular repair.²⁰ ^{, 21} Topical aloe vera has facilitated wound healing in controlled human research, as well.²² In one controlled trial, however, topical aloe vera gel was inferior to conventional management of surgical wounds.²³ What Else Is This Supplement Used For?

Supplement	Amount	Why
Chamomile	Apply an ointment containing 2% chamomile extract or standardized for chamazulene and bisabolol content three to four times daily	Topically applied chamomile can be used to speed wound healing.
Chamomile Apply an ointment containing 2% chamomile extract or standardized for chamazulene and bisabolol content three to four times daily A topical preparation of chamomile combined with corticosteroids and antihistamines has been used to speed wound healing in elderly people with stasis ulcers caused by inadequate circulation,²⁴ as well as in people who had tattoos removed.²⁵ Topical use of chamomile ointment was also found to successfully treat mild stasis ulcers in elderly bedridden patients.²⁶ Traditional herbalists sometimes recommend the topical use of herbs such as St. John’s wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice. What Else Is This Supplement Used For?

Supplement	Amount	Why
Chondroitin Sulfate Topical	Refer to label instructions	Applying an ointment containing chondroitin sulfate may speed healing of skin wounds. Learn More
Copper	2 to 4 mg daily	Copper plays a role in the strengthening of connective tissue and may help promote wound healing.
Copper 2 to 4 mg daily Copper is a required cofactor for the enzyme lysyl oxidase, which plays a role in the cross-linking (and strengthening) of connective tissue.²⁷ Doctors often recommend a copper supplement as part of a comprehensive nutritional program to promote wound healing. A typical amount recommended is 2–4 mg per day, beginning two weeks prior to surgery and continuing for four weeks after surgery. What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Gotu Kola	Take a standardized herbal extract providing 60 mg total triterpenoids once or twice per day	Applying an ointment containing gotu kola may speed healing of skin wounds.
Gotu Kola Take a standardized herbal extract providing 60 mg total triterpenoids once or twice per day One preliminary trial found that a gotu kola extract helped heal infected wounds (unless they had reached bone).²⁸ A review of French studies suggests that topical gotu kola can help wounds.²⁹ One study found gotu kola extract helpful for preventing and treating enlarged scars (keloids).³⁰ Standardized extracts of gotu kola containing up to 100% total triterpenoids are generally taken, providing 60 mg once or twice per day. Animal studies have shown that constituents in gotu kola, called asiaticosides, increase antioxidant levels during wound healing and facilitate repair of connective tissues.³¹ ^{, 32} What Else Is This Supplement Used For?

Supplement	Amount	Why
Horse Chestnut	Apply topically	Horse chestnut contains a compound called aescin that acts as an anti-inflammatory and reduces swelling after trauma, particularly sports injuries, surgery, and head injury.
Horse Chestnut Apply topically Horse chestnut contains a compound called aescin that acts as an anti-inflammatory and reduces edema (swelling with fluid) following trauma, particularly sports injuries, surgery, and head injury.³³ A topical aescin preparation is popular in Europe for the treatment of acute sprains during sporting events. What Else Is This Supplement Used For?

Supplement	Amount	Why
Hyaluronic Acid	1% solution for ears	Topically applied hyaluronic acid is sometimes used in skin wound dressings to improve healing.
Hyaluronic Acid 1% solution for ears Topical application of hyaluronic acid and related compounds is sometimes used in skin wound dressings to improve healing.³⁴ One controlled trial found a hyaluronic acid compound helpful for healing skin ulcers associated with chronic venous insufficiency.³⁵ Improved healing of nasal surgery wounds with topical hyaluronic acid was reported in one controlled study,³⁶ but not in another.³⁷ A double-blind study found improved healing of perforated eardrums in patients using drops of 1% sodium hyaluronate.³⁸ Whether oral hyaluronic acid supplements might improve wound healing has not been investigated. What Else Is This Supplement Used For?

Supplement	Amount	Why
Ornithine Alpha-Ketoglutarate	10 to 30 grams daily	Supplementing with OKG has been shown to significantly improve wound healing and decrease the length of hospital stays.
Ornithine Alpha-Ketoglutarate 10 to 30 grams daily Preliminary³⁹ and controlled⁴⁰ studies of people with severe burns and other types of injuries⁴¹ showed that supplementation with 10–30 grams of ornithine alpha-ketoglutarate (OKG) per day significantly improved wound healing and decreased the length of hospital stays. Improved healing from major trauma and surgery has also been demonstrated with oral supplements including several grams per day of glutamine.⁴² What Else Is This Supplement Used For?

Supplement	Amount	Why
Vitamin A	Take under medical supervision: 25,000 IU daily	Vitamin A plays a central role in wound healing and may be useful as a supplement or in a topical ointment.
Vitamin A Take under medical supervision: 25,000 IU daily Vitamin A plays a central role in wound healing,⁴³ but the effect of supplemental vitamin A in people who have suffered a minor injury and are not vitamin A-deficient remains unclear. Vitamin A supplements have been shown to improve healing in animal studies,⁴⁴ and may be especially useful in a topical ointment for skin injuries in people taking corticosteroid medications.⁴⁵ Although there are no studies in humans, some doctors recommend 25,000 IU of vitamin A per day, beginning two weeks prior to surgery and continuing for four weeks after surgery. What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Vitamin E	400 IU daily	Supplementing with vitamin E may enhance healing and prevent adhesion formation after surgery, applied topically, the vitamin may help prevent scarring.
Vitamin E 400 IU daily Animal studies have shown that supplementing with vitamin E can decrease the formation of unwanted adhesions following a surgical wound. In addition, wound healing was more rapid in animals fed a vitamin E-rich diet than in those fed a standard diet.⁴⁶ In another study, however, wound healing was inhibited by supplementation with a massive amount of vitamin E (equivalent to about 35,000 IU).⁴⁷ This adverse effect of vitamin E was prevented by supplementation with vitamin A. Although the relevance of these studies to humans is not clear, many doctors recommend supplementing with both vitamins A and E in order to enhance wound healing and prevent adhesion formation. Typical amounts recommended are 25,000 IU of vitamin A per day and 400 IU of vitamin E per day, beginning two weeks prior to surgery and continuing for four weeks after surgery. Topical application of vitamin E is sometimes recommended for preventing or treating post-injury scars, although only three controlled studies have been reported. Two of these trials found no effect on scar prevention after surgery,⁴⁸ ^{, 49} and one trial found vitamin E improved the effect of silicon bandages on large scars called keloids.⁵⁰ What Else Is This Supplement Used For? See Drug Interactions

Supplement	Amount	Why
Arginine	Refer to label instructions	Arginine appears to improve wound healing by increasing protein synthesis.
Arginine Arginine supplementation increases protein synthesis and improves wound healing in animals.⁵¹ Two controlled trials have shown increased tissue synthesis in surgical wounds in people given 17–25 grams of oral arginine per day.⁵²^{, 53} What Else Is This Supplement Used For?

Supplement	Amount	Why
Arnica Topical	Refer to label instructions	Some practitioners consider topically applied arnica to be among the best wound-healing herb available.
Arnica Topical Used topically, some practitioners consider arnica to be among the best vulnerary (wound-healing) herbs available.⁵⁴ Topical use of arnica is approved by the German government for improving wound healing.⁵⁵ Arnica is poisonous if taken internally.

Supplement	Amount	Why
Bladderwrack	Refer to label instructions	Alginic acid is one of the main constituents in bladderwrack. Calcium alginate has shown promise as an agent to speed wound healing.
Bladderwrack Alginic acid is one of the main constituents in bladderwrack (Fucus vesiculosus), a type of brown algae (seaweed). Calcium alginate has shown promise as an agent to speed wound healing in animal studies⁵⁶ but has not been demonstrated to be effective in humans. What Else Is This Supplement Used For?

Supplement	Amount	Why
Calendula	Refer to label instructions	Topically applied calendula can be used to speed wound healing.
Calendula Calendula flowers were historically considered beneficial for wound healing, reducing inflammation and fighting infection as a natural antiseptic.⁵⁷ Like echinacea, calendula is approved in Germany for use in treating poorly healing wounds.⁵⁸ Generally 1 tablespoon (15 grams) of calendula flowers is steeped in hot water for 15 minutes, then cloths are dipped into the liquid to make compresses. Such compresses should be applied for at least 15 minutes, initially several times per day, then tapering off as the wound improves. Traditional herbalists sometimes recommend the topical use of herbs such as St. John’s wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice. What Else Is This Supplement Used For?

Supplement	Amount	Why
Carnosine	Refer to label instructions	Carnosine, a small molecule composed of the amino acids histidine and alanine, appears to promote wound healing.
Carnosine Carnosine is a small molecule composed of the amino acids histidine and alanine. The exact biological role of carnosine is not completely understood, but animal research demonstrates that it promotes wound healing.⁵⁹ More research is warranted in this area. What Else Is This Supplement Used For?

Supplement	Amount	Why
Chaparral	Refer to label instructions	Chaparral has been used topically to decrease inflammation, and pain, and promote healing of minor wounds.
Chaparral Chaparral has been used topically to decrease inflammation, and pain, and promote healing of minor wounds.⁶⁰ For topical use, cloths can be soaked in oil preparations or tea of chaparral and applied several times per day (with heat if helpful) over the affected area. Powdered chaparral can be applied directly to minor wounds, after they have been adequately cleansed. What Else Is This Supplement Used For?

Supplement	Amount	Why
Chondroitin Sulfate Oral	Refer to label instructions	Supplementing with chondroitin sulfate may promote wound healing by providing the raw material needed by the body to manufacture connective tissue.
Chondroitin Sulfate Oral Glucosamine sulfate and chondroitin sulfate may both play a role in wound healing by providing the raw material needed by the body to manufacture connective tissue found in skin, tendons, ligaments, and joints.⁶¹ Test tube and animal studies have found that these substances, and others like them, can promote improved tissue healing.⁶²^{, 63}^{, 64}^{, 65}^{, 66} One controlled trial in humans found that wounds healed with greater strength when they were treated topically with a chondroitin sulfate-containing powder.⁶⁷ However, no research has investigated the value of oral supplements of glucosamine or chondroitin for wound healing in humans. What Else Is This Supplement Used For?

Supplement	Amount	Why
Comfrey	Refer to label instructions	Comfrey has anti-inflammatory properties that may decrease bruising and help heal wounds when the herb is applied topically.
Comfrey Comfrey has anti-inflammatory properties that may decrease bruising when the herb is applied topically.⁶⁸ Comfrey is also widely used in traditional medicine as a topical application to help heal wounds.⁶⁹Witch hazel can also be used topically to decrease inflammation and to stop bleeding.⁷⁰ Native Americans used poultices of witch hazel leaves and bark to treat wounds, insect bites, and ulcers.⁷¹Horsetail can be used both internally and topically to decrease inflammation and promote wound healing.⁷² What Else Is This Supplement Used For?

Supplement	Amount	Why
Echinacea	Refer to label instructions	Echinacea is used among European practitioners of herbal medicine to promote wound healing.
Echinacea Echinacea is used among European practitioners of herbal medicine to promote wound healing⁷³ and is approved by the German government for this use.⁷⁴ Creams or ointments are applied several times a day to minor wounds. What Else Is This Supplement Used For?

Supplement	Amount	Why
Glucosamine Sulfate Oral	Refer to label instructions	Supplementing with glucosamine sulfate may promote wound healing by providing the raw material needed by the body to manufacture connective tissue.
Glucosamine Sulfate Oral Glucosamine sulfate and chondroitin sulfate may both play a role in wound healing by providing the raw material needed by the body to manufacture connective tissue found in skin, tendons, ligaments, and joints.⁷⁵ Test tube and animal studies have found that these substances, and others like them, can promote improved tissue healing.⁷⁶^{, 77}^{, 78}^{, 79}^{, 80} One controlled trial in humans found that wounds healed with greater strength when they were treated topically with a chondroitin sulfate-containing powder.⁸¹ However, no research has investigated the value of oral supplements of glucosamine or chondroitin for wound healing in humans.

Supplement	Amount	Why
Horsetail	Refer to label instructions	Horsetail can be used both internally and topically to decrease inflammation and promote wound healing.
Horsetail Comfrey has anti-inflammatory properties that may decrease bruising when the herb is applied topically.⁸² Comfrey is also widely used in traditional medicine as a topical application to help heal wounds.⁸³Witch hazel can also be used topically to decrease inflammation and to stop bleeding.⁸⁴ Native Americans used poultices of witch hazel leaves and bark to treat wounds, insect bites, and ulcers.⁸⁵Horsetail can be used both internally and topically to decrease inflammation and promote wound healing.⁸⁶ What Else Is This Supplement Used For?

Supplement	Amount	Why
Plantain Topical	Refer to label instructions	Topically applied plantain can be used to speed wound healing.
Plantain Topical Traditional herbalists sometimes recommend the topical use of herbs such as St. John’s wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice. What Else Is This Supplement Used For?

Supplement	Amount	Why
St. John’s Wort	Refer to label instructions	Topically applied St. John’s wort can be used to speed wound healing.
St. John’s Wort Caution: It is likely that there are many drug interactions with St. John's wort that have not yet been identified. St. John's wort stimulates a drug-metabolizing enzyme (cytochrome P450 3A4) that metabolizes at least 50% of the drugs on the market.⁸⁷ Therefore, it could potentially cause a number of drug interactions that have not yet been reported. People taking any medication should consult with a doctor or pharmacist before taking St. John's wort. Traditional herbalists sometimes recommend the topical use of herbs such as St. John’s wort, calendula, chamomile, and plantain, either alone or in combination, to speed wound healing. Clinical trial in humans have not yet validated this traditional practice. What Else Is This Supplement Used For?

Supplement	Amount	Why
Tea Tree	Refer to label instructions	Tea tree oil may be applied topically to skin wounds, although it is not recommended for burns.
Tea Tree Australian Aboriginals used the leaves of tea tree to treat cuts and skin infections, crushing and applying them to the affected area. Modern herbalists recommend tea tree oil (at a strength of 70–100%) applied moderately in small areas at least twice per day to the affected areas of skin.⁸⁸ For a variety of reasons, some researchers have suggested that tea tree oil should not be used to treat burns.⁸⁹ What Else Is This Supplement Used For?

Supplement	Amount	Why
Witch Hazel	Refer to label instructions	Witch hazel can be used topically to decrease inflammation and to stop bleeding.
Witch Hazel Comfrey has anti-inflammatory properties that may decrease bruising when the herb is applied topically.⁹⁰ Comfrey is also widely used in traditional medicine as a topical application to help heal wounds.⁹¹Witch hazel can also be used topically to decrease inflammation and to stop bleeding.⁹² Native Americans used poultices of witch hazel leaves and bark to treat wounds, insect bites, and ulcers.⁹³Horsetail can be used both internally and topically to decrease inflammation and promote wound healing.⁹⁴ What Else Is This Supplement Used For?

References

Last Review: 05-11-2011

Learn more about Aisle7, the company.

The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2011.

© 1995-2011 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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